Abbiamo analizzato 29 esami RM di 20 pazienti affetti da NF1, tutti con lesioni iperintense nelle sequenze T2-pesate che sono tipiche di questa malattia. 5 pazienti sono stati seguiti con follow-up. L'eterogeneità di queste lesioni è dimostrata dalla loro diversa evolutività: alcune sembrano scomparire gradualmente, altre si manifestano in controlli successivi.
BarkovichAJ: Pediatric Neuroimaging, NormanD, (ed). Raven Press, New York1990: 123–147.
3.
BognannoJREdwardsMK: Cranial MR imaging in neurofibromatosis. Am J Neuroradiol, 9: 461–468, 1988.
4.
BoritARichardsonEP: The biological and clinical behaviours of the pilocytic astrocytomas of the optic pathways. Brain, 105: 161–187, 1982.
5.
BraffmanBHBilaniukLTZimmermanRA: The Central Nervous System manifestations of the phakomatoses on MR. Radiol Clin North Am, 26: 773–800, 1988.
6.
BrownEWRiccardiVM: Mr imaging of optic pathways in patients with neurofibromatosis. Am J Neuroradiol, 8: 1031–1036, 1987.
7.
CanaleDJDebinJ: In: Handbook of clinical neurology: The phakomatoses. Vol. 14. VinkenPSBruynGW, (eds). Amsterdam1972: 132–162.
8.
CawthonRMWeissR: A major segment of the neurofibromatosis type 1 gene: Cdna sequence, genomic structure, and point mutations. Cell, 62: 193–201, 1990.
9.
DellLABrownMS: Physiologic intracranial calcification with hyperintensity on MR imaging: Case report and experimental model. Am J Neuroradiol, 9: 1145–1148, 1988.
10.
De RecondoJHaguenauM: In: Handbook of clinical neurology: The phakomatoses. Vol 14. VinkenPSBruynGW, (eds). Amsterdam1972: 19–71.
11.
GebarskiSSGabrielsenTO: Posterior circulation intracranial arterial occlusive disease in neurofibromatosis. Am J Neuroradiol, 4: 1245–1246, 1983.
12.
GoldsteinSMCurlessRG: A new sign of neurofibromatosis on Magnetic Resonance Imaging of children. Arch Neurol, 46: 1222–1224, 1989.
13.
FlorisRSergiacomiGL. Il ruolo della risonanza magnetica nella diagnosi delle neurofibromatosi. Rivista di Neuroradiologia, 5 (Suppl 1): 101–104, 1992.
14.
HoltJF: Neurofibromatosis in children. Am J Radiol, 130: 615–639, 1978.
15.
HurstRWNewmanSACailWS: Multifocal intracranial MR abnormalities in neurofibromatosis. Am J Neuroradiol, 9: 293–296, 1988.
16.
LeoneRGSchatzkiSCWolpowER: Neurofibromatosis with extensive intracranial arterial occlusive disease. Am J Neuroradiol, 3: 572–576, 1982.
17.
MagnaldiSWhiteRMBryanRN: Lesioni encefaliche nella neurofibromatosi: Manifestazioni cliniche e aspetti tipici con la Risonanza Magnetica. Radiol Med, 80: 796–807, 1990.
18.
MirowitzSASartorKGadoM: High-intensity basal ganglia lesions on T1-weighted MR images in neurofibromatosis. Am J Radiol, 154: 369–373, 1990.
19.
National Institute of Health Consensus Development Conference: Neurofibromatosis. Arch Neurol, 45: 575–578, 1988.
20.
PomeranzSJSheltonJJ: MR of visual pathways in patients with neurofibromatosis. Am J Neuroradiol, 8: 831–836, 1987.
21.
Pou SerradellA: Lesions centrales dans les neurofibromatoses: Corrélations cliniques, d'IRM et histopathologiques. Essai de classification. Rev Neurol (Paris), 147: 17–27, 1991.
22.
RubensteinAEMytilineoauC: In: Advances in Neurology: Neurofibromatosis (von Rechlinghausen disease), vol 29. RiccardiVMMulvihilJJ, (eds). Raven Press, New York1981: 11–20.
23.
RubinsteinLJRussellDS: Pathology of tumors of the Nervous System. Edward Arnold (ed). London1989: 769–784.
24.
TamrazJCIba-ZizenMT: MRI in the central form of neurofibromatosis. J Neuroradiol, 14: 365–382, 1987.
25.
WallaceMRMarchukDA: Type 1 neurofibromatosis gene: Identification of a large transcript disrupted in three NF1 patients. Science, 249: 181–186, 1990.
26.
ZimmermanRAYachinisAT: Pathology of findings of cerebral high signal intensity in 2 patients with Type 1 Neurofibromatosis. Radiology, 185 (P) (suppl): 123, 1992.
