Genetic disorders affecting the central nervous system have a wide age range regarding onset of symptoms. A specific disease entity may have childhood onset or adult onset forms, whereas other disease entities may only yield symptoms in adulthood. Symptoms may be neurological or psychiatric including early dementia. It is important to recognize such diseases because the correct diagnosis may yield information on the mode of inheritance, prognosis and have an impact on the patient's treatment. Radiological examinations also provide further knowledge about these diseases and help us in understanding pathophysiology. Examples of some genetic diseases with adult-onset will be presented.
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