‘Double cortex’ is characterized by the presence of a well-defined and well-marginated layer of neurons that lie in the white matter in a location in which their migration to the cerebral cortex has been prematurely arrested. Here, we report a case where band heterotopia was seen in all the lobes of brain.
BarkovichAJJacksonDEJrBoyerRS: Band heterotopia: A newly recognized neuronal migration anomaly. Radiology171: 455–458, 1989.
2.
PalminiAAndermannFAicardiJ: Diffuse cortical dysplasia, or the “double cortex” syndrome: The clinical and epileptic spectrum in 10 patients. Neurology41: 1656–1662, 1991.
3.
BarkovichAJChuangSHNormanD: MR of neuronal migration anomalies. Am J Neuroradiol8: 1009–1017, 1987.
4.
des PortesVFrancisFPinardJ-M: Doublecortin is the major gene causing X—linked subcortical laminar heterotopia (SCLH). Hum Mol Genet7: 1063–1070, 1998.
5.
EksiogluYZSchefferIECardenasP: Periventricular heterotopia: An X-linked dominant epilepsy locus causing aberrant cerebral cortical development. Neuron16: 77–87, 1996.
6.
PilzDTMatsumotoNMinnerathS: LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation. Hum Mol Genet7: 2029–2037, 1998.
7.
PilzDKucJMatsumotoN: Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1. Hum Mol Genet8: 1757–1760, 1999.
8.
BarkovichAJGuerriniRBattagliaG: Band heterotopia: Correlation of outcome with MR imaging parameters. Ann Neurol36: 609–617, 1994.
9.
AllenKWalshC: Genes that regulate neuronal migration in the cerebral cortex. Epilepsy Res36: 143–154, 1999.
10.
GhoshAShatzCJ: A role for subplate neurons in the patterning of connections from thalamus to neocortex. Development117: 1031–47, 1993.
11.
JammesJLGillesFH: Telencephalic development: Matrix volume and isocortex and allocortex surface areas. In: GillesFHLevitonADoolingEC, eds The Developing Human Brain. Boston: John Wright, PSG Incorporated1983: 87–93.
