While they tend to cluster normally around the anterior commissure, prominent PVSs can be seen normally in virtually any location in the brain, at virtually all ages. Giant “tumefactive” PVSs can assume a spectrum of bizarre appearances and should not be mistaken for neoplasm. The pial-lined, interstial fluid-filled PVSs provide a natural route of spread for a spectrum of infectious, inflammatory, demyelinating and neoplastic diseases to involve the brain parenchyma.
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