Bilateral perisylvian polymicrogyria is among the cortical abnormalities caused by late neuronal migration due to both genetic and environmental factors. It is associated with variable changes in motor development and facio-pharyngoglosso-masticatory diplegia with varying language disorders. Epilepsy is more common in lesions extending posteriorly. We describe two cases of non-familial bilteral perisylvian polymicrogyria with different clinical features but sharing signs of severe neonatal encephalopathy mimicking an anoxic-ischaemic lesion. MR studies were done at nine and 20 months in the first patient and at two weeks and three months in the second.
