We present a case of cerebral thrombosis in a newborn with no apparent risk factors but who further investigations proved to have Protein C deficiency. Symptoms of presentation were seizures; the diagnosis was made by Magnetic Resonance Imaging (MRI) and angioMRI; a thrombolytic therapy with recombinant tissue plasminogen activator (rTPA) followed by a prophylaxis with low molecular weight heparin (LMWH) were successfully implemented.
Given the advances in imaging techniques (Power Doppler examination via the mastoid approach), cerebral ultrasound allowed us to suspect thrombosis, to monitor treatment efficacy and to confirm complete resolution, in this case.
