The number of elderly patients admitted with diagnosis of cerebral aneurysms is markedly increasing worldwide. Treatment in this group of patients is certainly more difficult than in the young subjects and not many reports deal with their management.
Many factors must be considered deciding if to pursue treatment. Patients admitted after bleeding (subarachnoid haemorrhage, SAH) have a different prognosis from young subjects and those harboring unruptured vascular malformations.
We have analyzed the literature on the basis of this distinction.
AmacherALFergusonGG: How old people tolerate intracranial surgery for aneurysm. Neurosurgery1: 242–244, 1977.
2.
Artiola i FortunyLAdamsCBTBriggsM: Surgical mortality in an aneurysm population: effects of age, blood pressure and preoperative neurological stage. J Neurol Neurosurg Psychiatry43: 879–882, 1980.
ChasonJLHindmanWM: Berry aneurysms of the circle of Willis: Results of a planned autopsy study. Neurology8: 41–44, 1958.
5.
ChungRBobS: Management outcomes for ruptured and unruptured aneurysms in the elderly. Neurosurgery47: 827–832, 2000.
6.
EllenbogenBK: Subarachnoid haemorrhage in the elderly. Geront Clin12: 115–120, 1970.
7.
FisherCMKistlerJPDavisJM: Relation of cerebral vasospasm to subarachnoid haemorrhage visualized by computerized tomographic scanning. Neurosurgery6: 1–9, 1980.
8.
FridrikssonSMHillmanJ: Intracranial aneurysm surgery in the 8th and 9th decades of life: impact on population-based management outcome. Neurosurgery37: 627–632, 1995.
9.
FujitaKLinXP: Risk factors for severe subarachnoid haemorrhage following aneurysmal rupture. No Shinkei Geka21: 885–889, 1993.
10.
InagawaTYamamotoM: Management of elderly patients with aneurysmal subarachnoid haemorrhage. J Neurosurg69: 332–339, 1988.
11.
InagawaTHiranoA: Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol34: 361–365, 1990.
12.
InagawaT: Management outcome in the elderly patient following subarachnoid haemorrhage. J Neurosurg78: 554–561, 1993.
13.
InagawaT: What are the actual incidence and mortality rates of subarachnoid haemorrhage?Surg Neurol47: 47–53, 1997.
14.
International Study of unruptured intracranial aneurysms investigators: Unruptured intracranial aneurysms: Risk of rupture and risks of surgical intervention. N Engl J Med339: 1725–1733, 1998.
15.
IwamotoHKiyoharaY: Prevalence of intracranial aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period: The Hisayama study. Stroke30: 1390–1395, 1999.
16.
LanzinoGKassellNF: Age and outcome after aneurysmal subarachnoid haemorrhage: why do older patients fare worse?J Neurosurg Sep85(3): 410–418, 1996.
17.
JohnstonSCGressDRKahnJG: Which unruptured cerebral aneurysms should be treated? A cost-utility analysis. Neurology52: 1806–1815, 1999.
18.
KasselNFTornerJC: The international cooperative study on the timing of aneurysm surgery. Part I: overall management results. J Neurosurg73: 18–36, 1990.
19.
KasselNFTornerJC: The international cooperative study on the timing of aneurysm surgery. Part II: surgical results. J Neurosurg73: 37–47, 1990.
20.
KingJTJrBerlinJAFlammES: Morbidity and mortality from elective surgery for asymptomatic, unruptured, intracranial aneurysms: A meta-analysis. J Neurosurg81: 827–842, 1994.
21.
KiyoharaYUedaK: Incidence and prognosis of subarachnoid haemorrhage in a Japanese rural community. Stroke20: 1150–1155, 1989.
22.
MartindaleBVGarfieldJ: Subarachnoid haemorrhage above the age of 59: are intracranial investigations justified?Br Med J1: 465–466, 1978.
23.
McKissockWPaineKWEWalshLS: An analysis of the results of treatment of ruptured intracranial aneurysms. Report of 772 consecutive cases. J Neurosurg17: 762–776, 1960.
24.
MelamedELavyS: Reduction in regional cerebral blood flow during normal aging in man. Stroke11: 31–35, 1980.
25.
MeyerCHALoweD: Subarachnoid haemorrhage: older patients have low cerebral blood flow. Br Med J285: 1149–1153, 1982.
26.
PhillipsLHIIWhisnantJP: The unchanging pattern of subarachnoid haemorrhage in a community. Neurology30: 1034–1040, 1980.
27.
RaaymakersTWMRinkelGJ: Mortality and morbidity of surgery for unruptured intracranial aneurysms: A meta-analysis. Stroke29: 1531–1538, 1998.
28.
SaccoRLWolfPA: Subarachnoid and intracranial haemorrhage: Natural history, prognosis, and precursive factors in the Framingham study. Neurology34: 847–854, 1984.
29.
RosenørnJEskesenVSchmidtK: Age as a prognostic factor after intracranial aneurysm rupture. Br J Neurosurg1: 335–341, 1987.
30.
SaccoRLWolfPA: Subarachnoid and intracerebral haemorrhage: natural history, prognosis, and precursive factors in the Framingham Study. Neurology34: 847–854, 1984.
31.
SakakiSOhtaS: Outcome in elderly patients with ruptured intracranial aneurysm. Clin Neurol Neurosurg91: 21–27, 1989.
32.
SartiCTuomilehtoJ: Epidemiology of subarachnoid haemorrhage in Finland from 1983 to 1985. Stroke22: 848–853, 1991.
33.
SenguptaRPLassmanLPHankinsonJ: Scope of surgery for intracranial aneurysm in the elderly: a preliminary report. Br Med J2: 246–247, 1978.
34.
SkultetyFMNishiokaH: Report on the Cooperative study of intracranial aneurysms and subarachnoid haemorrhage. Section VIII, Part 2. The results of intracranial surgery in the treatment of aneurysms. J Neurosurg25: 683–704, 1966.
35.
YamashitaKKashiwagiS: Cerebral aneurysms in the elderly in Yamaguchi, Japan: Analysis of the Yamaguchi data bank of cerebral aneurysm from 1985 to 1995. Stroke28: 1926–1931, 1997.
36.
YasuiTYaguraH: Management of elderly patients with aneurysmal subarachnoid haemorrhage. No Shinkei Geka20: 651–656, 1992.
37.
BradačGBSturaGBerguiM: Endovascular treatment of cerebral aneurysms. Part one. Rivista di Neuroradiologia15: 537–548, 2002.
38.
BerguiMSturaGBradačGB: Endovascular treatment of cerebral aneurysms. Part two. Rivista di Neuroradiologia15: 549–559, 2002.