The biomechanical properties of human septal cartilage have yet to be fully defined and thereby limits our ability to compare tissue-engineered constructs to native tissue. In this study, we analyzed the tensile properties of human nasal septal cartilage with respect to axis of tension, age group, and gender.
Methods
Fifty-five tensile tests were run on human septal specimens obtained from 28 patients. Samples obtained in the vertical and anterior–posterior (both above and within the maxillary crest) axes were subjected to equilibrium and dynamic tensile testing.
Results
The average values for strength, failure strain, equilibrium modulus and dynamic modulus were not found to be significantly different with respect to axis of tension testing, age group, or gender. Tensile results for septal cartilage were as follows: equilibrium modulus 3.01 ± 0.39 MPa, dynamic modulus 4.99 ± 0.49 MPa, strength 1.90 ± 0.24 MPa, and failure strain 0.35 ± 0.03 mm/mm.
Conclusion
We confirm that septal cartilage has weaker tensile properties compared to articular cartilage and found no difference in strength with respect to age, gender, or axis of tension (isotropic).
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References
1.
RandolphM.A., AnsethK., and YaremchukM.J.Tissue engineering of cartilage.Clin Plast Surg30: 519–537, 2003.
2.
RuddermanR.H., and MullenR.L.Biomechanics of the facial skeleton.Clin Plast Surg19: 11–29, 1992.
3.
ChampyM., and LoddeJ.P.Mandibular synthesis. Placement of the synthesis as a function of mandibular stress [in French].Rev Stomatol Chir Maxillofac77: 971–976, 1976.
4.
ChampyM., and LoddeJ.P.Study of stresses in the fractured mandible in man. Theoretical measurement and verification by extensometric gauges in situ[in French].Rev Stomatol Chir Maxillofac78: 545–551, 1977.
5.
LiJ.T., ArmstrongC.G., and MowV.C.Proceedings of the Biomechanics Symposium Transactions of the American Society of Mechanical Engineers (ASME), 1983.
6.
AkizukiS., MowV.C., MullerF.Tensile properties of human knee joint cartilage. II. Correlations between weight bearing and tissue pathology and the kinetics of swelling.J Orthop Res5: 173–186, 1987.
7.
KempsonG.E.Relationship between the tensile properties of articular cartilage from the human knee and age.Ann Rheum Dis41: 508–511, 1982.
8.
WooS.L., AkesonW.H., and JemmottG.F.Measurements of non-homogeneous, directional mechanical properties of articular cartilage in tension.J Biomech9: 785–791, 1976.
9.
WooS.L., LubockP., GomezM.A.Large deformation non-homogeneous and directional properties of articular cartilage in uniaxial tension.J Biomech12: 437–446, 1979.
10.
WooS.L., SimonB.R., KueiS.C., and AkesonW.H.Quasi-linear viscoelastic properties of normal articular cartilage.J Biomech Eng102: 85–90, 1980.
11.
ReindelE.S., AyrosoA.M., ChenA.C.Integrative repair of articular cartilage in vitro: Adhesive strength of the interface region.J Orthop Res13: 751–760, 1995.
12.
KempsonG.E., MuirH., PollardC., and TukeM.The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans.Biochim Biophys Acta297: 456–472, 1973.
13.
AkizukiS., MowV.C., MullerF.Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus.J Orthop Res4: 379–392, 1986.
14.
HomiczM.R., McGowanK.B., LottmanL.M.A compositional analysis of human nasal septal cartilage.Arch Facial Plast Surg5: 53–58, 2003.
15.
SnodellS.F., NandaR.S., and CurrierG.F.A longitudinal cephalometric study of transverse and vertical craniofacial growth.Am J Orthod Dentofacial Orthop104: 471–483, 1993.
16.
LaineT., and WarrenD.W.Effects of age, gender, and body size on nasal cross-sectional area in children.Eur J Orthod13: 311–316, 1991.
17.
ElliottD.M., NarmonevaD.A., and SettonL.A.Direct measurement of the Poisson's ratio of human patella cartilage in tension.J Biomech Eng124: 223–228, 2002.
18.
KempsonG.E.Age-related changes in the tensile properties of human articular cartilage: A comparative study between the femoral head of the hip joint and the talus of the ankle joint.Biochim Biophys Acta1075: 223–230, 1991.
19.
WeightmanB.Tensile fatigue of human articular cartilage.J Biomech9: 193–200,1976.
20.
BroomN.D.Structural consequences of traumatizing articular cartilage.Ann Rheum Dis45: 225–234, 1986.
21.
ChenM.H., and BroomN.On the ultrastructure of softened cartilage: A possible model for structural transformation.J Anat192: 329–341,1998.
22.
BuckwalterJ.A., and MankinH.J.Articular cartilage: Tissue design and chondrocyte-matrix interactions.Instr Course Lect47: 477–486, 1998.
23.
FryH.J.Interlocked stresses in human nasal septal cartilage.Br J Plast Surg19: 276–278, 1966.
24.
MurakamiW.T., WongL.W., and DavidsonT.M.Applications of the biomechanical behavior of cartilage to nasal septoplastic surgery.Laryngoscope92: 300–309, 1982.
25.
FryH.J.The distorted residual cartilage strut after submucous resection of the nasal septum.Br J Plast Surg21: 170–172, 1968.
26.
FryH., and RobertsonW.V.Interlocked stresses in cartilage.Nature215: 53–54, 1967.
27.
FarmerJ.M., MartinD.F., BolesC.A., and CurlW.W.Chondral and osteochondral injuries. Diagnosis and management.Clin Sports Med20: 299–320, 2001.
28.
GlasgoldM.J., KatoY.P., ChristiansenD.Mechanical properties of septal cartilage homografts.Otolaryngol Head Neck Surg99: 374–379, 1988.
29.
RotterN., TobiasG., LeblM.Age-related changes in the composition and mechanical properties of human nasal cartilage.Arch Biochem Biophys403: 132–140, 2002.
30.
ParkS.S., JinH.R., ChiD.H., and TaylorR.S.Characteristics of tissue-engineered cartilage from human auricular chondrocytes.Biomaterials25: 2363–9236, 2004.
31.
ChiaS.H., SchumacherB.L., KleinT.J.Tissue-engineered human nasal septal cartilage using the alginate-recovered-chondrocyte method.Laryngoscope114: 38–45, 2004.
32.
ChenA.C., PfisterB.E., NakagawaK.Effect of long-term culture on tensile properties and collagen network maturation in tissue-engineered cartilage. In press.
33.
WilliamsonA.K., MasudaK., ThonarE.J., and SahR.L.Growth of immature articular cartilage in vitro: Correlated variation in tensile biomechanical and collagen network properties.Tissue Eng9: 625–634, 2003.
34.
WilliamsonA.K., ChenA.C., MasudaK.Tensile mechanical properties of bovine articular cartilage: Variations with growth and relationships to collagen network components.J Orthop Res21: 872–880, 2003.
35.
ElliottD.M., NarmonevaD.A., and SettonL.A.Direct measurement of the Poisson's ratio of human patella cartilage in tension.J Biomech Eng124: 223–228, 2002.
36.
TengS., XuY., ChengM., and LiY.Biomechanical properties and collagen fiber orientation of temporomandibular joint discs in dogs: 2. Tensile mechanical properties of the discs.J Craniomandib Disord5: 107–14, 1991.
