Work of Breathing: How to Define and when to Measure?

Campbell EJM . The respiratory muscles and the mechanics of breathing. Chicago: Yearbook, 1958.

Otis AB . The work of breathing. In: Fenn WO , Rahn H , eds. Handbook of Physiology: Respiration. Washington DC: American Physiological Society, 1964:463–476.

Marini JJ , Capps JS , Culver BH . The inspiratory work of breathing during assisted mechanical ventilation. Chest 1985;87(5):612–618.

Tobin MJ , Van de Graaff WB . Monitoring of lung mechanics and work of breathing. In: Tobin MJ , ed. Principles and practice of mechanical ventilation. New York: McGraw-Hill, 1994:967–1004.

Banner MJ , Jaeger MJ , Kirby RR . Components of the work of breathing and implications for monitoring ventilator-dependent patients. Crit Care Med 1994;22(3):515–523.

Marini JJ , Rodriguez RM , Lamb V. Bedside estimation of the inspiratory work of breathing during mechanical ventilation. Chest 1986;89(1):56–63.

Marini JJ , Rodriguez RM , Lamb V. The inspiratory workload of patient-initiated mechanical ventilation. Am Rev Respir Dis 1986;134(5):902–909.

Sassoon CS , Mahutte CK , Te TT , Simmons DH , Light RW . Work of breathing and airway occlusion pressure during assist-mode mechanical ventilation. Chest 1988;93(3):571–576.

Bolder PM , Healy TE , Bolder AR , Beatty PC , Kay B. The extra work of breathing through adult endotracheal tubes. Anesth Analg 1986;65(8):853–859.

Fiastro JF , Habib MP , Quan SF . Pressure support compensation for inspiratory work due to endotracheal tubes and demand continuous positive airway pressure. Chest 1988;93(3):499–505.

Brochard L , Rua F , Lorino H , Lemaire F , Harf A. Inspiratory pressure support compensates for the additional work of breathing caused by the endotracheal tube. Anesthesiology 1991;75(5):739–745.

Bersten AD , Rutten AJ , Vedig AE , Skowronski GA . Additional work of breathing imposed by endotracheal tubes, breathing circuits, and intensive care ventilators. Crit Care Med 1989;17(7):671–677.

Hirsch C , Kacmarek RM , Stanek K. Work of breathing during CPAP and PSV imposed by the new generation mechanical ventilators: a lung model study. Respir Care 1991;36(8):815–828.

Kacmarek RM , Stanek KS , McMahon KM , Wilson RS . Imposed work of breathing during synchronized intermittent mandatory ventilation by five home care ventilators. Respir Care 1990;35(5):405–414.

MacIntyre NR . New forms of mechanical ventilation in the adult. Clin Chest Med 1988;9(1):47–54.

Takahashi T , Takezawa J , Kimura T , Nishiwaki K , Shimada Y. Comparison of inspiratory work of breathing in T-piece breathing, PSV, and pleural pressure support ventilation (PPSV). Chest 1991;100(4):1030–1034.

Sassoon CS , Lodia R , Rheeman CH , Kuei JH , Light RW , Mahutte CK . Inspiratory muscle work of breathing during flow-by, demand-flow, and continuous-flow systems in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1992;145(5):1219–1222.

Branson RD . Decreasing the work of breathing: how much of a change is important? Respir Care 1994;39(3):187–189.

Sassoon CSH , Te TT , Mahutte CK , Light RW . Airway occlusion pressure; an important indicator for successful weaning in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1987;135(1):107–113.

Shikora SA , Bistrian BR , Borlase BC , Blackburn GL , Stone MD , Benotti PN . Work of breathing: reliable predictor of weaning and extubation. Crit Care Med 1990;18(2):157–162.

Davis K , Campbell R , Branson R , Johnson D , Anderson G , Porembka D. Does the oxygen cost of breathing (O₂COB) reflect the mechanical work of breathing? Crit Care Med 1993;21:S242.

Browning JA , Linberg SE , Turney SZ , Chodoff P. The effects of a fluctuating Fio₂ on metabolic measurements in mechanically ventilated patients. Crit Care Med 1982;10(2):82–85.

Blanch PB , Banner MJ . A new respiratory monitor that enables accurate measurement of work of breathing: a validation study. Respir Care 1994;39(9):897–905.

Niknam J , Chandra A , Adams AB , Nahum A , Ravenscraft SA , Marini JJ . Effect of a nasogastric tube on esophageal pressure measurement in normal adults. Chest 1994;106(1):137–141.

Marini JJ , Smith TC , Lamb V J . External work output and force generation during synchronized intermittent mechanical ventilation: effect of machine-assistance on breathing effort. Am Rev Respir Dis 1988;138(5):1169–1179.