Clinical Effects of Hypoxemia and Tissue Hypoxia

Stedman TL . Stedman's medical dictionary, 25th ed. Baltimore: Williams & Wilkins, 1990:756.

Youmans WB . Hypoxia, asphyxia, dysbarism, oxygen therapy, and resuscitation. In: Brobeck JR , ed. Best & Taylor's physiological basics of medical practice, 9th ed. Baltimore: Williams & Wilkins, 1973:63–90.

Goudsouzian N , Karamanian A. Physiology for the an-esthesiologist, 2nd ed. Norwalk CT: Appleton-Century-Crofts, 1984.

Dickinson JG . High altitude cerebral edema: cerebral acute mountain sickness. Semin Respir Infect 1983;5:151.

York EL , Jones RL , Menon D , Sproule BJ . Effects of secondary polycythemia on cerebral blood flow in chronic obstructive pulmonary disease. Am Rev Respir Dis 1980;121:813–818.

Brenner RP . The electroencephalogram in altered states of consciousness. Neurol Clin 1985;3(3):615–631.

Dulfano MJ , Ishikawa S. Hypercapnia: mental changes and extrapulmonary complications. Ann Intern Med 1965;63:829.

Phillipson EA . Regulation of breathing during sleep. Am Rev Respir Dis 1977;115(6, Part 2):217–224.

Guilleminault C , Tilkian A , Dement WC . The sleep ap-nea syndromes. Annu Rev Med 1976;27:465–484.

Rolfe I , Olson LG , Saunders NA . Long-term acceptance of continuous positive airway pressure in obstructive sleep apnea. Am Rev Respir Dis 1991;144(5):1130–1133.

Fletcher EC , Lesske J , Qian W , Miller CC III , Unger T. Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension 1992;19(6, Part 1):555–561.

Van Den Arrdweg JG , Karemaker JM . Repetitive ap-neas induce periodic hypertension in normal subjects through hypoxia. J Appl Physiol 1992;72(3):821–827.

McDonald DM . Role of glomus cells as dopaminergic interneurons in the chemoreceptive function of the ca-rotid body. Adv Biochem Psychopharmacol 1977;16:265–274.

Kressin NA , Nielsen AM , Laravuso R , Bisgard GE . Domperidone-induced potentiation of ventilatory re-sponses in awake goats. Respir Physiol 1986;65(2):169–180.

Walley KR , Becker CJ , Hogan RA , Teplinsky K , Wood LD . Progressive hypoxemia limits left ventricular oxy-gen consumption and contractility. Semin Anesthesia 1987;4(3):188–195.

Heavner JE , Dryden CF Jr , Sanghani V , Huemer G , Bessire A , Badgwell JM . Severe hypoxia enhances cen-tral nervous system and cardiovascular toxicity of bupi-vacaine in lightly anesthetized pigs. Anesthesiology 1992;77:142–147.

Von Euler US , Liljestrand G. Observations of the pul-monary artery blood pressure in the cat. Acta Physiol Scand 1946;12:301–307.

Bergman NA . Hypoxic pulmonary vasoconstriction. Semin Anesthesia 1987;6(3):188–195.

Sobol BJ , Bottex G , Emirgil C , . Gaseous diffusion from alveoli to pulmonary vessels of considerable size. Circ Res 1963;13:71.

Staub NC . Site of hypoxic pulmonary vasoconstriction. Chest 1985;88(4, Suppl):240S–245S.

Hales CA . The site and mechanism of oxygen sensing for the pulmonary vessels. Chest 1985;88(4, Suppl):235S–240S.

Lloyd TC Jr . Influences of PO2 and pH on resting and active tensions of pulmonary arterial strips. J Appl Physiol 1967;22:1101–1109.

Barer GR . Reactivity of the vessels of collapsed and ventilated lungs to drugs and hypoxia. Circ Res 1966;18:366–378.

Hauge A. Role of histamine in hypoxic pulmonary hy-pertension in the rat: I. Blockade or potentiation of en-dogenous amines, kinins and ATP. Circ Res 1968;22:371–383.

Radermacher P , Santak B , Becker H , Falke KJ . Pros-taglandin E1 and nitroglycerin reduce pulmonary cap-illary pressure but worsen ventilation-perfusion dis-tributions in patients with adult respiratory distress syndrome. Anesthesiology 1989;70:601–606.

Bakhle YS , Ferreira SH . Lung metabolism of eicosan-oids: prostaglandins, prostacyclin, thromboxane and leu-kotrienes. In: Handbook of physiology. Washington DC: American Physiological Society, 1985;3(1):365.

Palmer RMJ , Ferrige AG , Moncada S. Nitric oxide re-lease accounts for the biological activity of endotheli-um-derived relaxing factor. Nature 1987;327:524–526.

Burghuber OC . Nifedipine attenuates acute hypoxic pul-monary vasoconstriction in patients with chronic ob-structive pulmonary disease. Respiration 1987;52:86–93.

Benumof JL . Hypoxic pulmonary vasoconstriction and infusion of sodium nitroprusside (editorial). Anesthesi-ology 1979;50:481–483.

Prewitt RM , Wood LDH . Nitroprusside increases pul-monary shunt and improves left ventricular function in dogs with oleic acid pulmonary edema (abstract). Am Rev Respir Dis 1978;117(4, Part 2):382.

Simonneau G , Escourrou P , Duroux P , Lockhart A. In-hibition of hypoxic pulmonary vasoconstriction by ni-fedipine. N Engl J Med 1981;304(26):1582–1585.

Furman WR , Summer WR , Kennedy TP , Sylvester JT . Comparison of the effects of dobutamine, dopamine, and isoproterenol on hypoxic pulmonary vasocon-striction in the pig. Crit Care Med 1982;10(6):371–374.

Epstein RM , Wheeler HO , Frumin M , Habif DV , Pap-per EM , Bradley SE . The effect of hypercapnia on es-timated hepatic blood flow, circulating splanchnic blood volume, and hepatic sufobromophthalein clearance dur-ing general anesthesia in man. J Clin Invest 1961;40:592.

Miller TA . Mechanisms of stress-related mucosal dam-age. Am J Med 1987;83(6A):8–14.

Fiddian-Green RD , McGough E , Pittenger G , Rothman E. Predictive value of intramural pH and other risk fac-tors for massive bleeding from stress ulceration. Gastro-enterology 1983;85:613–620.

Aranha GV , Pickleman J , Pifarre R , Scanlon PJ , Gunnar RM . The reasons for gastrointestinal consultation after cardiac surgery. Am Surg 1984;50:301–304.

Haas GS , Warshaw AL , Daggett WM , Aretz HT . Acute pancreatitis after cardiopulmonary bypass. Am J Surg 1985;149:508–515.

Fiddian-Green RG , Amelin PM , Herrmann JB , Arous E , Cutler BS , Schiedler M , . Prediction of the develop-ment of sigmoid ischemia on the day of aortic opera-tions: indirect measurements of intramural pH in the co-lon. Arch Surg 1986;121:654–660.

Gordon AS , Zanjani ED . Hormones and erythropoiesis. In: Greenwalt TJ , Jamieson GA , eds. Formation and de-struction of blood cells. Philadelphia: JB Lippincott, 1970:34–64.

Cheek TG , Gutsche BB . Maternal physiologic altera-tions during pregnancy. In: Schneider SM , Levinson G , eds. Anesthesia for obstetrics, 2nd ed. Baltimore: Wil-liams & Wilkins, 1987:3–13.

Huch A , Huch R , Schneider H , Rooth G. Continuous transcutaneous monitoring of fetal oxygen tension dur-ing labour. Br J Obstet Gynaecol 1977;84(Suppl 1):1–39.

Benumof JL . Respiratory physiology and respiratory function during anesthesia. In: Miller RD , ed. Anesthe-sia, 3rd ed, Vol 1. New York: Churchill Livingstone, 1990:544.

Landis EM , Pappenheimer JR . Exchange of substances through the capillary walls. In: Hamilton WE , ed. Hand-book of physiology: circulation, Vol II, Chapter 29. Washington DC: American Physiological Society, 1963.

Fiaccadori E , Vezzani A , Coffrini E , Guariglia A , Ron-da N , Tortorella G , . Cell metabolism in patients un-dergoing major valvular heart surgery: relationship with intra and postoperative hemodynamics, oxygen trans-port, and oxygen utilization patterns. Crit Care Med 1989;17:1286–1292.

Shoemaker WC , Appel PL , Kram HB , Waxman K , Lee T-S . Prospective trial of supranormal values of sur-vivors as therapeutic goals in high-risk surgical patients. Chest 1988;94:1176–1186.

Shoemaker WC , Appel PL , Kram HB . Tissue oxygen debt as a determinant of lethal and nonlethal post-operative organ failure. Crit Care Med 1988;16(11):1117–1120.

Taitelman U. Acute cyanide poisoning. In: Hall JB , Schmidt GA , Wood LDH , eds. Principles of critical care. New York: McGraw-Hill, 1992:2125–2129.

Chen KK , Rose CL , Clowes GHA . Comparative values of several antidotes in cyanide poisoning. Am J Med Sci 1934;188:767–781.

Hug EL . Intoxication par acid cyanhydrique. C R Soc Biol (Paris) 1933;112:511–513.

Refsum HE . Relationship between state of conscious-ness and arterial hypoxemia and hypercapnia in patients with pulmonary insufficiency, breathing air. Clin Sci 1963;25:361–367.

Nikaidoh H , Leonard SR , Morris-Copeland M. Car-diothoracic surgery: perioperative principles. In: Levin DL , Morriss FC , eds. Essentials of pediatric intensive care. St Louis: Quality Medical Publishing Inc, 1990:459–469.

Sanders JM . Life-threatening complications of sickle cell disease. In: Levin DL , Morriss FC , eds. Essentials of pediatric intensive care. St Louis: Quality Medical Publishing Inc, 1990:383–385.

Weinberger LM , Gibbon MH , Gibbon JH Jr . Temporary arrest of the circulation to the central nervous system. Arch Neurol Psych 1940;43(4):615–634.

Leigh JM . The pulmonary circulation. In: Scientific foundations of anaesthesia-the basics of intensive care, 4th ed. Chicago: Oxford/Year Book Medical Publishers, 1990:193–204.

Sykes MK , Davies DM , Chakrabarti MK , Loh L. The effect of inhalation anaesthetic agents on the pulmonary vasculature of the isolated perfused cat lung. Br J An-aesth 1973;45:114–115.

Domino KB , Borowec L , Alexander CM , Williams JJ , Chen L , Marshall C , . Influence of isoflurane on hy-poxic pulmonary vasoconstriction in dogs. Anesthes-iology 1986;64:423–429.

Mathers J , Benumof JL , Wahrenbrock EA . General an-esthetics and regional hypoxic pulmonary vasocon-striction. Anesthesiology 1977;46:111–114.

Rogers SN , Benumof JL . Halothane and isoflurane do not impair arterial oxygenation during one lung ventila-tion in patients undergoing thoracotomy (abstract). Anesthesiology 1983;59:A532.

Augustine SD , Benumof JL . Halothane and isoflurane do not impair arterial oxygenation during one lung ven-tilation in patients undergoing thoracotomy (abstract). Anesthesiology 1984;61:A484.

Benumof JL . One-lung ventilation and hypoxic pul-monary vasoconstriction: implications for anesthetic management. Anesth Analg 1985;64:821–833.

Dripps RD , Eckenhoff JE , Vandam LD . The immediate postoperative period: recovery and intensive care. In: Introduction to anesthesia: the principles of safe practice, 6th ed. Philadelphia: WB Saunders Co, 1982:410–420.

Bailey PL , Pace NL , Ashburn MA , Moll JW , East KA , Stanley TH . Frequent hypoxemia and apnea after seda-tion with midazolam and fentanyl. Anesthesiology 1990;73(5):826–830.

Al-Khishali T , Padfield A , Perks ER , Thornton JA . Car-dio-respiratory effects of nitrous oxide: oxygen:halo-thane anaesthesia administered to dental outpatients in the upright position. Anaesthesia 1978;33(2):184–188.

Bell GD , Antrobus JH , Lee J , Coady T , Morden A. Bo-lus or slow titrated injection of midazolam prior to upper gastrointestinal endoscopy? Relative effect on ox-ygen saturation and prophylactic value of supplemental oxygen. Aliment Pharmacol Ther 1990;4(4):393–401.

Bell GD , Antrobus JH , Lee J , Coady TJ , Morden A. Pat-tern of breathing during upper gastrointestinal endos-copy: implications for administration of supplemental oxygen. Aliment Pharmacol Ther 1991;5(4):399–404.

Dodson SR , Hensley FA Jr , Martin DE , Larach DR , Morris DL . Continuous oxygen saturation monitoring during cardiac catheterization in adults. Chest 1988;94 (1):28–31.

Comroe JH Jr , Botelho S. The unreliability of cyanosis in the recognition of arterial anoxemia. Am J Med Sci 1947;214:1–6.

Tinker JH , Dull DL , Caplan RA , Ward RJ , Cheney FW . Role of monitoring devices in prevention of anesthetic mishaps: a closed claims analysis. Anesthesiology 1989;71:541–546.

Cote CJ , Goldstein EA , Cote MA , Hoaglin DC , Ryan JF . A single-blind study of pulse oximetry in children. Anesthesiology 1988;68(2):184–188.

Hess D , Kacmarek RM . Techniques and devices for monitoring oxygenation. Respir Care 1993;38:646–671.