Clinical Aspects of Aerosol Physics

Morrow PE . Conference on the scientific basis of respiratory therapy: aerosol therapy. Aerosol characterization and deposition. Am Rev Respir Dis1974;110(6, Part 2):88–99.

Yu CP , Nicolaides P , Soong TT . Effect of random airway sizes on aerosol deposition. Am Ind Hyg Assoc J1979;40:999–1005.

Dolovich M , Chambers C , Newhouse M. Characterization of three systems used to deliver pentamidine (P) aerosol (abstract). Am Rev Respir Dis1990;141(4, Part 2):A153.

Ilowite JS , Baskin MI , Sheetz MS , Abd AG . Comparison of the delivered dose and regional distribution of aerosolized pentamidine using different delivery systems (abstract). Am Rev Respir Dis1990;141(4, Part 2):A53.

Morrow PE . Factors determining hygroscopic aerosol deposition in airways. Physiol Rev1986;66:330–375.

Martin GP , Bell AE , Marriott C. An in vitro method for assessing particle deposition from metered pressurized aerosols and dry powder inhalers. Int J Pharm1988;44:57–63.

Ryan G , Dolovich MB , Obminski G , Cockcroft DW , Juniper E , Hargreave FE , et al. Standardisation of inhalation provocation tests: influence of nebulizer output, particle size and method of inhalation. J Allergy Clin Immunol1981;67:156–161.

Dolovich MB , Ruffin RE , Roberts RS , Newhouse MT . Optimal delivery of aerosols from metered dose inhalers. Chest1981;83:911–915.

Newman SP , Pavia D , Clarke SW . How should pressurized beta-adrenergic bronchodilator be inhaled? Eur J Respir Dis1981;62:3–21.

Murakami G , Igarashi T , Adachi Y , Matsuno M , Adachi Y , Sawai M , et al. Measurement of bronchial hyperreactivity in infants and preschool children using a new method. Ann Allergy1990;64:383–387.

Newman SP , Bateman JRM , Pavia D , Clarke SW . The importance of breath-holding following the inhalation of pressurized aerosol bronchodilators. In: Baran D , ed. Recent advances in aerosol therapy: first Belgian symposium on aerosols in medicine. Brussels: UCB Pharmaceuticals, 1979:117–122.

Auty RM , Brown K , Neale MG , Snashall PD . Respiratory tract deposition of sodium cromoglycate is highly dependent upon technique of inhalation using the Spinhaler. Br J Dis Chest1987;81:371–380.

Pedersen S. How to use a Rotahaler. Arch Dis Child1986;61:11–14.

Vidgren M , Paronen P , Vidgren P , Vainio P , Nuutinen J. In-vivo evaluation of the new multiple dose powder inhaler and Rotahaler using gamma scintigraphy. Acta Pharm Nord1990;1:3–10.

Persson G , Gruvstad E , Stahl E. A new multiple dose powder inhaler (Turbuhaler) compared with a pressurized inhaler in a study of terbutaline in asthmatics. Eur Respir J1988;1:681–684.

Dolovich M , Vanzieleghem M , Hidinger K-G , Newhouse MT . Influence of inspiratory flow rate on the response to terbutaline sulphate inhaled via the Turbuhaler (abstract). Am Rev Respir Dis1988;137(4, Part 2):433.

Santolicandro A , Ruschi S , Fornai E , Giuntini C. Imaging of ventilation in chronic obstructive pulmonary disease. J Thorac Imag1986;1:36–53.

Monrigal JP , Granry JC , Vilayleck S , Lejeune JJ , Chavellat M. Effects of the endotracheal state on the progression of antibiotics administered by aerosol route (abstract). Am Rev Respir Dis1990;141(4, Part 2):A525.

Xu JB , Yu CP . The effects of age on deposition of inhaled aerosols in the human lung. Aerosol Sci Technol1986;5:349–357.

Dolovich MB , Sanchis J , Rossman C , Newhouse MT . Aerosol penetrance: a sensitive index of peripheral airways obstruction. J Appl Physiol1976;40:468–471.

Ilowite JS , Gorvoy JD , Smaldone GC . Quantitative deposition of aerosolized gentamicin in cystic fibrosis. Am Rev Respir Dis1987;136:1445–1449.

Kim CS , Lewars GA , Sackner MA . Measurement of total lung aerosol deposition as an index of lung abnormality. J Appl Physiol1988;64:1527–1536.

Chan TL , Lippmann M. Experimental measurement and empirical modelling of the regional deposition of inhaled particles in humans. Am Ind Hyg Assoc J1980;41:399–409.

Dolovich M. Physical principles underlying aerosol therapy. J Aerosol Med1989;2:171–186.

O'Doherty MJ , Thomas SH , Page CJ , Bradbeer C , Nunan TO , Bateman NT . Does inhalation of pentamidine in the supine position increase deposition in the upper part of the lung? Chest1990;97:1343–1348.

Salzman GS , Pyszczynski DR . Oral pharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol1988;81:424–428.

Dolovich M , Ruffin R , Corr D , Newhouse M. Clinical evaluation of a simple demand inhalation MDI aerosol delivery device. Chest1983;84:36–44.

Newman SP , Millar AB , Lennard-Jones TR , Moren F , Clarke SW . Improvement of pressurized aerosol deposition with Nebuhaler spacer device. Thorax1984;39:935–941.

König P , Gayer D , Kantak A , Kreutz C , Douglass B , Hordvik NL . A trial of metaproterenol by metered-dose inhaler and two spacers in preschool asthmatics. Pediatr Pulmonol1988;5:247–251.

Fuller HD , Dolovich MB , Posmituck G , Wong Pack W , Newhouse MT . Pressurized aerosol versus jet aerosol delivery to mechanically ventilated patients: comparison of dose to the lungs. Am Rev Respir Dis1990;141:440–444.

Flavin M , MacDonald M , Dolovich M , Coates G , O'Brodovich H. Aerosol delivery to the lung with an infant ventilator. Pediatr Pulmonol1986;2:36–39.

MacIntyre NR , Silver RM , Miller CW , Schuler F , Coleman RE . Aerosol delivery in intubated, mechanically ventilated patients. Crit Care Med1985;13:81–84.

Dolovich M. Lung deposition of aerosols: methods and assessments. In: Epstein SW , ed. Metered dose inhalers. Proceedings of an international workshop. Mississauga, Canada: Astra Pharmaceuticals, 1984:27–37.

Brain JD , Valberg PA . Deposition of aerosols in the respiratory tract. Am Rev Respir Dis1979;120:1325–1373.

Juniper EF , Kline PA , Vanzieleghem MA , Ramsdale EH , O'Byrne PM , Hargreave FE . Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in non-steroid-dependent asthmatics. Am Rev Respir Dis1990;142:832–836.

Howarth PH , Djukanovic R , Wilson J , Wilson S , Britten K , Roche W , et al. Airway inflammation and asthma: the influence of inhaled beclomethasone dipropionate. Clin Exp Allergy1990;20(1, Suppl):94.