Agreement Between Single-Breath Derecruitment and Nitrogen Multiple-Breath Washin–Washout Methods for Estimating Functional Residual Capacity in Mechanically Ventilated Children
Restricted accessResearch articleFirst published online 2026
Agreement Between Single-Breath Derecruitment and Nitrogen Multiple-Breath Washin–Washout Methods for Estimating Functional Residual Capacity in Mechanically Ventilated Children
ChiumelloD, ChidiniG, CalderiniE, et al.Respiratory mechanics and lung stress/strain in children with acute respiratory distress syndrome. Ann Intensive Care2016; 6: 11; doi: 10.1186/s13613-016-0113-0
2.
BikkerIG, ScohyTV, AdJJC, et al.Measurement of end-expiratory lung volume in intubated children without interruption of mechanical ventilation. Intensive Care Med2009; 35: 1749–1753; doi: 10.1007/s00134-009-1579-0
3.
SivanY, DeakersTW and NewthCJ. Functional residual capacity in ventilated infants and children. Pediatr Res1990; 28: 451–454; doi: 10.1203/00006450-199011000-00006
4.
GriecoDL, PintaudiG, BongiovanniF, et al.Recruitment-to-inflation ratio assessed through sequential end-expiratory lung volume measurement in acute respiratory distress syndrome. Anesthesiology2023; 139: 801–814; doi: 10.1097/ALN.0000000000004716
5.
ChenL, Del SorboL, GriecoDL, et al.Potential for lung recruitment estimated by the recruitment-to-inflation ratio in acute respiratory distress syndrome. A clinical trial. Am J Respir Crit Care Med2020; 201: 178–187; doi: 10.1164/rccm.201902-0334OC
6.
LanteriCJ and SlyPD. Changes in respiratory mechanics with age. J Appl Physiol (1985)1993; 74: 369–378; doi: 10.1152/jappl.1993.74.1.369
7.
Bar-YishayE, ShulmanDL, BeardsmoreCS, et al.Functional residual capacity in healthy preschool children lying supine. Am Rev Respir Dis1987; 135: 954–956; doi: 10.1164/arrd.1987.135.4.954
8.
EmeriaudG, López-FernándezYM, IyerNP, et al.; Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) Group on behalf of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Executive summary of the second international guidelines for the diagnosis and management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2). Pediatr Crit Care Med2023; 24: 143–168; doi: 10.1097/PCC.0000000000003147
9.
WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. Available from: https://www.who.int/publications/i/item/924154693X [Last accessed: 18Aug, 2025].
10.
KhadilkarV, YadavS, AgrawalKK, et al.; Indian Academy of Pediatrics Growth Charts Committee. Revised IAP growth charts for height, weight and body mass index for 5- to 18-year-old Indian children. Indian Pediatr2015; 52: 47–55; doi: 10.1007/s13312-015-0566-5
11.
GrivansC, LundinS, StenqvistO, et al.Positive end-expiratory pressure-induced changes in end-expiratory lung volume measured by spirometry and electric impedance tomography. Acta Anaesthesiol Scand2011; 55: 1068–1077; doi: 10.1111/j.1399-6576.2011.02511.x
12.
OlegårdC, SöndergaardS, HoultzE, et al.Estimation of functional residual capacity at the bedside using standard monitoring equipment: a modified nitrogen washout/washin technique requiring a small change of the inspired oxygen fraction. Anesth Analg2005; 101: 206–212, table of contents; doi: 10.1213/01.ANE.0000165823.90368.55
13.
ShaikhFAR, VenugopalNK, BhaskaranMK, et al.Estimation of transpulmonary driving pressure, strain, and lung-specific elastance using volumetric methods in invasively ventilated children—A feasibility study. Pediatric Crit Care Med2026; 27: 458–468; doi: 10.1097/PCC.0000000000003905
14.
ProttiA, CressoniM, SantiniA, et al.Lung stress and strain during mechanical ventilation: any safe threshold? Am J Respir Crit Care Med2011; 183: 1354–1362. [Erratum in Am J Respir Crit Care Med. 2012 Jan 1;185(1):115]; doi: 10.1164/rccm.201010-1757OC
15.
BrewerL, OrrJ, FulcherE, et al.Evaluation of a CO2 partial rebreathing functional residual capacity measurement method for use during mechanical ventilation. J Clin Monit Comput2011; 25: 397–404; doi: 10.1007/s10877-011-9318-9