Neurologists should be familiar with the spectrum of central nervous system (CNS) pathology that renal transplants patients are prone to. We are presenting a case of posttransplant lymphoproliferative disorder of the CNS to highlight less commonly described imaging findings and review this disease entity.
Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN / SRTR 2010 Annual Data Report. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation; 2011. http://www.srtr.org/annual_reports/2010. Accessed April 18, 2012.
2.
MorgansAKReshefRTsaiDE. Posttransplant lymphoproliferative disorder following kidney transplant. Am J Kidney Dis. 2010;55(1):168–180.
NaborsLPalmerCJulianBPrzekwasAKewC. Isolated central nervous system posttransplant lymphoproliferative disorder treated with high-dose intravenous methotrexate. Am J Transplant. 2009;9(5):1243–1248.
5.
SwerdlowSH; International Agency for Research on Cancer, World Health Organization. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: International Agency for Research on Cancer; 2008.
6.
PatchellR. Neurological complications of organ transplantation. Ann Neurol. 1994;36(5):688–703.
7.
CavaliereRPetroniGLopesMBSchiffD. Primary central nervous system post-transplantation lymphoproliferative disorder: an International Primary Central Nervous System Lymphoma Collaborative Group Report. Cancer. 2010;116(4):863–870.
8.
PickhardtPWippoldF. Neuroimaging in posttransplantation lympoproliferative disorder. AJR Am J Roentgneol. 1999;172(4):1117–1121.
VaglioAManentiLManciniCEBV-associated leukoencephalopathy with late onset of central nervous system lymphoma in a kidney transplant recipient. Am J Transplant. 2010;10(4):947–951.
11.
HamadaniMMartinLKBensonDMCopelanEADevineSMHofmeisterCC. Central nervous system post-transplant lymphoproliferative disorder despite negative serum and spinal fluid Epstein–Barr virus DNA PCR. Bone Marrow Transplant. 2007;39(4):249–251.
12.
Castellano-SanchezALiSQianJLagooAWeirEBratD. Primary central nervous system posttransplant lymphoproliferative disorders. Am J Clin Pathol. 2004;121(2):246–253.
13.
HessR. Routine Epstein-Barr virus diagnostics from the laboratory perspective: still challenging after 35 years. J Clin Microbiol. 2004;42(8):3381–3387.
14.
TsaiDEDouglasLAndreadisCEBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial. Am J Transplant. 2008;8(5):1016–1024.
15.
SnanoudjRDurrbachALeblondVPrimary brain lymphomas after kidney transplantation: presentation and outcome. Transplantation. 2003;76(6):930–937.