Abstract
Background. Synthetic graft supplements such as Augment (recombinant human platelet-derived growth factor-BB [rhPDGF-BB] and beta-tricalcium phosphate [β-TCP]) are increasingly used to promote fusion in foot and ankle arthrodesis. However, mid- to long-term outcomes remain underreported. This study assessed union rates and time to union with and without graft supplementation in ankle and subtalar fusions. Methods. A retrospective review of 112 patients from 3 centers was conducted. Patients who received synthetic grafts formed the case group; those without any graft formed the control group. Postoperative radiographs and CT scans were used to assess union status and time to union. Statistical analysis was performed using SPSS (P < .05 significant). Results. Patients receiving graft supplementation had significantly faster union (160.5 ± 116.2 days) than controls (248.4 ± 282.3 days, P < .01). Nonunion rates did not differ significantly between groups (P = .71). Conclusion. Synthetic graft supplementation accelerates time to union in ankle and subtalar arthrodesis, potentially enabling earlier recovery and reduced rehabilitation costs. Further research is warranted.
Get full access to this article
View all access options for this article.