Neurothekeomas are benign connective tissue tumors probably of nerve sheath origin. Making diagnosis is often difficult, because of many histological similar looking tumors. Immunostaining of S-100 protein is a helpful method for differentiation. We report a case of subungual neurothekeoma affecting the little toe, which is to our knowledge the first to be described in the literature. In spite of an incomplete excision of the tumor with tails reaching to the base of the specimen, no recurrence after 1-year follow-up was observed.
Levels of Evidence: Therapeutic, Level IV: Case Study
GallagerRLHelwigEB. Neurothekeoma—a benign cutaneous tumor of neural origin. Am J Clin Pathol. 1980;74:759-764.
2.
ArgenyiZBLeBoitPESanta CruzDSwansonPEKutznerH. Nerve sheath myxoma (neurothekeoma) of the skin: light microscopic and immunohistochemical reappraisal of the cellular variant. J Cutan Pathol. 1993;20:294-303.
3.
ConnollyMHickeyJRIntzedyLPawadeJde BerkerDA. Subungual neurothekeoma. J Am Acad Dermatol. 2005;52:159-162.
4.
FetschJFLaskinWBHallmanJRLuptonGPMiettinenM. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol. 2007;31:1103-1114.
5.
LaskinWBFetschJFMiettinenM. The “neurothekeoma”: immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. Hum Pathol. 2000;31:1230-1241.
6.
PaulusWJellingerKPerneczkyG. Intraspinal neurothekeoma (nerve sheath myxoma). A report of two cases. Am J Clin Pathol. 1991;95:511-516.
7.
TiffeeJCPulitzerDR. Nerve sheath myxoma of the oral cavity: case report and review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82:423-425.
8.
BarnhillRLDickersinGRNickeleitV. Studies on the cellular origin of neurothekeoma: clinical, light microscopic, immunohistochemical, and ultrastructural observations. J Am Acad Dermatol. 1991;25:80-88.
9.
WardJLPrietoVGJosephAChevrayPKronowitzSSturgisEM. Neurothekeoma. Otolaryngol Head Neck Surg. 2005;132:86-89.
10.
SageRJLopiccoloMCLaunganiAGKoubaDJ. Mohs micrographic surgery for the treatment of cellular neurothekeoma and review of its use in surgical management of benign tumors. Dermatol Surg. 2010;36:1214-1218.
