The concomitant presence of osteomyelitis and diabetic Charcot neuroarthropathy of the foot and ankle places those patients affected at increased risk for limb loss. Antibiotic-loaded cement has been reported to be useful in the treatment of deep soft tissue and joint infections. The authors present an overview of this adjunctive treatment modality and present a case report using antibiotic-loaded cement beads in staged reconstruction for Charcot ankle osteomyelitis.
Sohn MW, Stuck RM, Pinzur M., Lee TA, Budiman-Mak E.Lower-extremity amputation risk after Charcot arthropathy and diabetic foot ulcer. Diabetes Care. 2010;33:98-100.
2.
van Baal J., Hubbard R., Game F., Jeffcoate W.Mortality associated with acute Charcot foot and neuropathic foot ulceration . Diabetes Care. 2010;33:1086-1089.
3.
Lipsky BAOsteomyelitis of the foot in diabetic patients. Clin Infect Dis. 1997;25:1318-1326.
4.
Trepman E., Nihal A., Pinzur MSCurrent topics review: Charcot neuroarthropathy of the foot and ankle . Foot Ankle Int. 2005;26:46-63.
5.
Roeder B., Van Gils CC, Maling S.Antibiotic beads in the treatment of diabetic pedal osteomyelitis . J Foot Ankle Surg. 2000;39:124-130.
6.
Kent ME, Rapp RP, Smith KMAntibiotic beads and osteomyelitis: here today, what’s coming tomorrow?Orthopedics.2006;29:599-603.
7.
Armstrong DG , Findlow AH, Oyibo SO, Boulton AJM.The use of absorbable antibiotic-impregnated calcium sulphate pellets in the management of diabetic foot infections. Diabetes Med. 2001;18:942-943.
8.
Stabile DE, Jacobs AMLocal antibiotic treatment of soft tissue and bone infections of the foot . J Am Podiatr Med Assoc. 1990;80:345-353.
9.
Buchholz HW, Engelbrecht H.Depot effects of various antibiotics mixed with Palacos resins. Chirurg. 1970;41:511-515.
10.
Buchholz HW , Gartmann HDInfection prevention and surgical management of deep insidious infection in total endoprosthesis. Chirurg . 1972; 43:446-453.
11.
Cunningham A., Demarest G., Rosen P., DeCoster TAAntibiotic bead production. Iowa Orthop J. 2000;20:31-35.
12.
Masri BA, Duncan CP, Beauchamp CPLong-term elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system . J Arthroplasty. 1998;13:331-338.
13.
Marcinko DEGentamicin-impregnated PMMA beads: an introduction and review. J Foot Surg. 1985;24:116-121.
14.
Calhoun JH, Klemm K., Anger DM, Mader JTUse of antibiotic-PMMA beads in the ischemic foot. Orthopedics . 1994;17:453-458.
15.
Schade VL, Roukis TSThe role of polymethylmethacrylate antibiotic-loaded cement in addition to debridement for the treatment of soft tissue and osseous infections of the foot and ankle. J Foot Ankle Surg. 2010 ;49:55-62.
16.
Stapleton JJ , Belczyk R., Zgonis T.Revisional Charcot foot and ankle surgery . Clin Podiatr Med Surg. 2009;26:127-139.
17.
Belczyk R., Ramanujam CL, Capobianco CM, Zgonis T.Combined midfoot arthrodesis, muscle flap coverage, and circular external fixation for the chronic ulcerated Charcot deformity. Foot Ankle Spec. 2010;3:40-44.
