Chondromyxoid fibroma rarely arises in the distal phalanx of the toe. It shows a wide spectrum of histology, mimicking other primary bone tumors. A 40-year-old woman had persistent swelling of her big toe after a minor injury a few years ago before a consultation. A radiographic and magnetic resonance imaging study suggested a highly aggressive tumor. Amputation was performed, and pathology of the lesion showed chondromyxoid fibroma.
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