Environmental stressors delay cutaneous wound healing and significantly impact patient survival rates. Traditional wound medications suffer from low delivery efficiency and susceptibility to degradation. Microneedle technology, characterized by its minimally invasive nature and high efficiency, significantly enhances transdermal drug delivery capabilities, while nanomaterials improve therapeutic efficacy through superior drug protection and controlled-release properties. The combination of these two technologies synergistically enables rapid wound repair and reduces the risk of complications. Current research predominantly focuses on single-component analyses (with only nine related studies indexed in Web of Science from 2014 to 2025), lacking systematic investigation into their synergistic mechanisms. This review innovatively establishes a classification system for microneedle–nanomaterial combinations, elucidating their fabrication processes, functional characteristics, and synergistic enhancement mechanisms, thereby providing a critical theoretical reference for the field of cutaneous repair.
Impact Statement
This study pioneers a systematic classification and mechanistic analysis of synergistic microneedle–nanomaterial systems for advanced wound healing and cutaneous repair. By elucidating fabrication strategies, functional enhancements, and therapeutic mechanisms, it bridges critical knowledge gaps in transdermal delivery and tissue regeneration. The framework enables precise engineering of combinatorial platforms to overcome barriers like drug degradation, biofilm resistance, and dysregulated inflammation. This work accelerates clinical translation of minimally invasive, multifunctional therapies, offering transformative solutions for chronic wounds, scarring, and infections. It establishes a foundational roadmap for next-generation dermatological innovation and personalized regenerative medicine.
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