Nanocomposite Hydrogels for Wound Management: A Bibliometric Review of Research Trends and Developments

Abstract

The unique advantages and broad applicability of nanocomposite hydrogels in wound care have become an indispensable driving force for innovative therapeutic strategies. However, comprehensive reviews of their latest research progress, application trends, and strategies remain insufficient. To address this, the present study employs bibliometric methods to systematically analyze the literature on nanocomposite hydrogels in wound care, covering various dimensions, including publication years, major contributing countries and institutions, core authors, publication distribution, and keyword co-occurrence networks. The analysis reveals a significant upward trend in academic attention to this field, with a steady increase in publications. Subsequently, we delve into four research hotspots, including the intelligent responsiveness of nanocomposite hydrogels, their adjustable drug release performance, their ability to promote cell proliferation and differentiation, and their innovative integration with stem cell therapy. Then, we explore the application features of nanocomposite hydrogels in wound healing, focusing on their roles in anti-inflammatory and infection control, promoting cell proliferation and angiogenesis, and providing moisturization and mechanical support. Finally, we discuss the challenges and emerging development trends in wound care using nanocomposite hydrogels, including deep integration with sensor technology, advancements toward artificial intelligence and multifunctionality, and optimization of biosafety. This study provides valuable insights and new perspectives for the future development of nanocomposite hydrogels in wound care.

Impact Statement

This article represents a significant scholarly contribution, employing comprehensive bibliometric and visualization methodologies to systematically analyze the body of literature concerning the application trends of nanocomposite hydrogels in wound care over the past 18 years. It meticulously identifies key contributions from leading nations such as China and the United States, delineates critical research subareas including microenvironment-responsive hydrogels, drug delivery systems, immune-regulatory applications, and stem cell integration, and forecasts future investigative directions centered on the design of sophisticated nanocomposite materials, precise control in drug release mechanisms, innovative hydrogel architectures, and a deeper understanding of the wound microenvironment’s influence on hydrogel performance.