Expanding the Druggable Proteome with Tech Advances

Abstract

Get full access to this article

View all access options for this article.

References

Zhang

Shokat

. Introduction: drugging the undruggable. Chem Rev. 2025;125(14):6433-6434. doi: 10.1021/acs.chemrev.5c00246.

Popow

Farnaby

Gollner

, et al. Targeting cancer with small-molecule pan-KRAS degraders. Science. 2024;385(6715):1338-1347. doi: 10.1126/science.adm8684.

Singh

Gleason

Fang

, et al. Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors. Nature. 2025;646(8085):734-745. doi: 10.1038/s41586-025-09433-w.

Gadd

Testa

Lucas

, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017;13(5):514-521. doi: 10.1038/nchembio.2329.

Zengerle

Chan

Ciulli

. Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem Biol. 2015;10(8):1770-7. doi: 10.1021/acschembio.5b00216.