Abstract
Background
Due to the scarcity of available data on the association between isolated oligohydramnios and the risk of small for gestational age (SGA), we undertook a meta-analysis to investigate this relationship.
Methods
PubMed (Medline), Web of Science, Scopus, and Science Direct were systematically queried up to February 26, 2024. Analysis was conducted using the random-effects model. Heterogeneity was evaluated among studies utilizing the chi-square test (χ2) and the I2 statistic. Additionally, we conducted regression tests including Egger’s and Begg’s tests to assess publication bias. We employed the modified Newcastle–Ottawa Scale (NOS) to assess the quality of observational articles. Statistical significance was set at a p-value less than 0.05 using Stata software, version 13.
Results
In the present meta-analysis, seven studies met the inclusion criteria and were included in the present systematic review and meta-analysis. The association between isolated oligohydramnios at term and the risk of SGA in crude studies was 2.22 (95% CI: 1.49, 2.94; I2 = 82.5%). Conversely, in adjusted studies, the association was 2.18 (95% CI: 1.78, 2.57; I2 = 0.0%).
Conclusion
The present meta-analysis indicates that isolated oligohydramnios is a significant risk factor for the SGA. Therefore, monitoring to diagnose SGA should be done in mothers with isolated oligohydramnios.
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Supplementary Material
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