A total of 10 chromanone derivatives (1–10), including two new compounds (1 and 2), were isolated from the fruits of Cynanchum thesiodes, and their structures were identified based on UV, IR, MS and NMR spectroscopic data, and comparison with those of reference compounds. The isolated compounds (1–10) were evaluated for their antiangiogenic activity by MTT assay using axitinib as a positive control. As a result, 1, 2, 3 and 9 exhibited important antiangiogenic activity with IC50 values of 13.8, 11.9, 43.6, and 74.8 μM, respectively.
YuanH.Q., ZuoC.X. (1992) Studies on the chemical constituents of Cynanchum thesioides.Acta Pharmaceutica Sinica, 27, 589–594.
2.
QiuS.X., ZhangZ.X., ZhouJ. (1990) The flavonol constituents of Cynanchum thesioides var. australe. Acta Botanica Yunnanica, 12, 227–228.
3.
SuL.H., WhangX.Q., HuangH., DuY. (2015) Review on characteristic mongolian medicine of Cynanchum thesioides.Journal of Medicine & Pharmacy of Chinese Minorities, 11, 55–56.
4.
WangD., ChenG., QiaoL., ZhangN., LvA.L., DangQ., PeiY.H. (2007) The chemical constituents from the fruits of Cynanchum thesioides (Freyn) K. Schum. Chinese Journal of Medicinal Chemistry, 17, 101–103.
5.
KongY. (2012) Pharmacology and pharmacology of some active ingredients of Cynanchum thesioides.Journal of Inner Mongolia University for Nationalities, 18, 26–27.
6.
AlaT.B.G. (2012) The development of modern research on Mongolian medicine of Cynanchum thesioides.Journal of North Pharmacy, 9, 33–34.
7.
ChangR.H. (2013) Comparative study on antioxidant activities of 100 medicinal plants from Inner Mongolia. Hohhot: The Master degree thesis of Inner Mongolia Normal University, 3.
8.
HeoD.S., ParkJ.G., HataK., DayR., HerbermanR.B., WhitesideT.L. (1990) Evaluation of tetrazolium-based semiautomatic colorimetric assay formeasurement of human antitumor cytotoxicity. Cancer Research, 50, 3681–3690.
9.
SasakiH., TaguchiH., EndoT., YosiokaI. (1982) The constituents of Ledebouriella seseloides wolff. I. structures of three new chromones. Chemical & Pharmaceutical Bulletin, 30, 3555–3562.
10.
SigstadE.E., CatalanC.A.N., DiazJ.G., HerzW. (1996) Chromanones, benzofurans and other constituents from Ophryosporus lorentzii.Phytochemistry, 42, 1443–1445.
11.
TsuiW.Y., BrownG.D. (1996) Chromones and chromanones from Baeckea frutescens.Phytochemistry, 43, 871–876.
12.
OmoloJ.O., AnkeH., SternerO. (2002) Hericenols A–D and a chromanone from submerged cultures of a Stereum species, 60, 431–435.
13.
TanakaN., KashiwadaY., NakanoT., ShibataH., HiguchiT., SekiyaM., IkeshiroY., TakaishiY. (2009) Chromone and chromanone glucosides from Hypericum sikokumontanum and their antihelicobacter pylori activities. Phytochemistry, 70, 141–146.
14.
WeiR.R., MaQ.G., LiT., LiuW.M., SangZ.P., LiM.B., LiuS.M. (2018) Carbazole alkalolds with antiangiogenic activities from Clausena sanki.Bioorganic Chemistry, 77, 387–392.
15.
ShangD.L., MaQ.G., WeiR.R. (2016) Cytotoxic phenylpropanoid glycosides from Cirsium japonicum.Journal of Asian Natural Products Research, 18, 1122–1130.
16.
FangL.L., LinW.W., QiuG.G., CaiY., YanP.C., CaiX.Q., LiW.C., TuH.F., DongJ.Y. (2015) Substolides A-G, germacrane sesquiterpenoids from Salvia substolonifera.Phytochemistry, 120, 28–35.
