Zingiber officinale (Ginger) is one of the most spice used worldwide and since antiquity it has been used in traditional medicine to treat different diseases. Although ginger is generally considered safe, there are no more information about the mechanism of its therapeutic action and its nutraceutical value. For these reasons the purpose of this work is to apply in vitro digestion model, as the first step in the study of its bioaccessibility, to understand which is the fate of its bioactive compounds after ingestion. This allow us to characterize which ginger metabolite are stable under gastrointestinal conditions and, thus, available for intestinal absorption. The aim of this study is to provide valuable information to better understand ginger pharmacological activities, paving the way for the definition of suitable dosage and source of food matrices to ensure nutritional efficacy.
SmanskiM.J. (2016) Synthetic biology to asses and expand nature's chemical diversity. Nature Review Microbiology, 14, 135–149.
2.
NewmanD.J. (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. Journal of Natural Products, 75, 311–335.
3.
CraggG.M. (2001) Medicinals for the millennia: the historical record. Annals of the New York Academy of Sciences, 953, 3–25.
4.
CohenR.J. (2002) Complementary and alternative medicine (CAM) use by older adults: a comparison of self-report and physician chart documentation. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 57, 223–227.
5.
ChauhanB. (2013) Current concepts and prospects of herbal nutraceutical: A review. Journal of Advanced Pharmaceutical Technology & Research, 4, 4–8.
6.
(a) ShaopengW. (2014) Biological properties of 6-gingerol: A brief review. Natural Product Communications, 9, 1027–1030; (b) Höferl M. (2015) Composition and comprehensive antioxidant activity of ginger (Zingiber officinale) essential oil from Ecuador. Natural Product Communications, 10, 1085-1090; (c) Makanjuola SA. (2015) Combination of antioxidants from different sources could offer synergistic benefits: A case study of tea and ginger blend. Natural Product Communications, 10, 1829-1832.
7.
SemwalR.B. (2015) Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry, 117, 554–568.
8.
SurhY.J. (1999) Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutation Research, 428, 305–327.
9.
GrzannaR. (2005) Ginger-an herbal medicinal product with broad anti-inflammatory actions. Journal of Medicinal Food, 8, 125–132.
10.
AliB.H. (2008) Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food and Chemical Toxicology, 46, 409–420.
11.
JoladS.D. (2004) Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry, 65, 1937–1954.
12.
BhattaraiS. (2001) The stability of gingerol and shogaol in aqueous solutions. Journal of Pharmaceutical Sciences, 90, 1658–1664.
13.
WohlmuthH. (2005) Gingerol Content of Diploid and Tetraploid Clones of Ginger (Zingiber officinale Roscoe). Journal of Agricultural and Food Chemistry, 53, 5772–5778.
14.
OkS. (2012) Optimization of extraction conditions for the 6-shogaol-rich extract from ginger (Zingiber officinale Roscoe). Preventive Nutrition and Food Science, 17, 166–171.
15.
(a) BodeA.M. (2011) The amazing and mighty ginger. Herbal Medicine: Biomolecular and Clinical Aspects, CRC Press/Taylor & Francis; (b) Stappen I. (2016) Influence of essential ginger oil on human psychophysiology after inhalation and dermal application. Natural Product Communications, 11, 1565-1568.
16.
KaulP.N. (2001) Alternative medicine: herbal drugs and their critical appraisal–part II. Progress in Drug Research, 57, 1–75.
17.
EscuderoE. (2010) Angiotensin I-converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat. Journal of Agricultural and Food Chemistry, 58, 2895–2901.
18.
Bailey-ShawY.A. (2008) Changes in the contents of oleoresin and pungent bioactive principles of Jamaican ginger (Zingiber officinale Roscoe) during maturation. Journal of Agricultural and Food Chemistry, 56, 5564–5571.
19.
(a) HiserodtR.D. (1998) Isolation of 6-, 8-, and 10-gingerol from ginger rhizome by HPLC and preliminary evaluation of inhibition of Mycobacterium avium and Mycobacterium tuberculosis.Journal of Agricultural and Food Chemistry, 46, 2504–2508; (b) Jiang H. (2005) Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 19, 2957-2964.
20.
BhupeshC.R. (1996) Extraction of ginger oil with supercritical carbon dioxide: Experiments and modeling. Industrial & Engineering Chemistry Research, 35, 607–612.
21.
LeeS. (2007) Liquid chromatographic determination of 6-, 8-, 10-gingerol, and 6-shogaol in ginger (Zingiber officinale) as the raw herb and dried aqueous extract. Journal of AOAC International, 90, 1219–1226.
22.
HuangT.C. (2011) Formation of 6-shogaol of ginger oil under different drying conditions. Drying Technology, 29, 1884–1889.
23.
PfeifferE. (2006) Microsomal hydroxylation and glucuronidation of [6]-gingerol. Journal of Agricultural and Food Chemistry, 54, 8769–8774.
24.
PaolellaS. (2015) Effect of dry-cured ham maturation time on simulated gastrointestinal digestion: Characterization of the released peptide fraction. Food Research International, 67, 136–144.
25.
VersantvoortC.H. (2005) Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 43, 31–40.
26.
FalavignaC. (2012) Masked fumonisins in processed food: co-occurrence of hidden and bound forms and their stability under digestive conditions. World Mycotoxin Journal, 5, 325–334.
