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Abstract

Two new acyl glucoses, 1,3,6-tri-O-(E)-caffeoyl-β-D-glucopyranoside (1) and 3,4-di-O-(E)-caffeoyl-α/β-D-glucopyranose (2), along with four known ones (3–6), were isolated from the roots of Aruncus sylvester. Their structures were elucidated on the basis of NMR spectroscopic analysis. Compounds 1 and 3 showed potent α-glucosidase inhibitory activity with IC₅₀ values of 1.16 μM and 0.71 μM, respectively.

Keywords

α-Glucosidase inhibitors Aruncus Sylvester Aruncus Phenylpropanoid glycosides Antioxidant

References

Editorial Committee of Flora Reipublicae Popularis Sinicae. (1974) Flora Reipublicae Popularis Sinicae; Academic Press: Beijing, Vol. 36, p. 71.

Guo

Z.J.

, Lü

J.X.

, Wang

J.X.

, Su

Y.F.

, Wei

Y.X.

, Zhu

Y.H.

(2003) Shaanxi Qi Yao; Shaanxi Science and Technology Press: Shaanxi, p. 196.

Que

, Su

Y.F.

, Yan

S.L.

, Zhou

Y.H.

, Gao

X.M.

(2013) Two new phenylpropanoid glycosides from the roots of Aruncus Sylvester. Journal of Asian Natural Products Research, 16, 158–162.

Sam

, Mam

A.N.

(2003) Caffeoyl sugar esters and an ellagitannin from Rubus sanctus. Phytochemistry, 63, 905–911.

Rja

, Kojima

(1985) Sweet potato root enzyme which catalyzes the formation of chlorogenic acid from 1-O-caffeoyl-D-glucose and D-quinic acid. Journal of the Agricultural Chemical Society of Japan, 49, 263–265.

Zhang

Y.J.

, Abe

, Tanaka

, Yang

C.R.

, Kouno

(2002) Two new acylated flavanone glycosides from the leaves and branches of Phyllanthus emblica. Chemical & Pharmaceutical Bulletin, 50, 841–843.

Kumar

, Ghosh

, Pal

B.C.

(2013) α-Glucosidase inhibitory terpenoids from Potentilla fulgens and their quantitative estimation by validated HPLC method. Journal of Functional Foods, 5, 1135–1141.

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Potent α-Glucosidase Inhibitors from the Roots of Aruncus sylvester

Abstract

Keywords

References

Supplementary Material