New Oxygenated Steroid from the Marine-Derived Fungus Aspergillus flavus

Abstract

One new oxygenated steroid, named aspersteroid A (1), and three known analogues (2–4) were isolated from the marine-derived fungus Aspergillus flavus collected from the Bohai Sea. Their structures were elucidated by spectroscopic analyses and by comparison with previously reported data. The absolute configuration of tetracyclic nucleus in 1 was assigned by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. All the compounds were evaluated for their cytotoxic and antibacterial activities.

Keywords

Fungus Aspergillus flavus Steroid Absolute configuration Bioactivity

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