The phytochemical investigation on roots of Leontodon hispidus L. subsp. hispidus, led to the isolation of nine sesquiterpene lactones including two eudesmanolides of santamarine type and three lactucin-like guaianolides together with four known phenolic compounds. The eudesmanolides – santamarine and 11β,13-dihydrosantamarine, guaianolides – matricarin, deacetylmatricarin and deacetylmatricarin 8-O-β-glucopyranoside, and phenolics – syringaldehyde, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone, syringin and dihydroconiferin were found for the first time in Leontodon.
EnkeN., GemeinholzerB., ZidornC. (2012) Molecular and phytochemical systematics of the subtribe Hypochaeridinae (Asteraceae, Cichorieae). Organisms Diversity & Evolution, 12, 1–16.
2.
Euro+Med (2006): Euro+Med PlantBase - the information resource for Euro-Mediterranean plant diversity. Published on the Internet http://ww2.bgbm.org/EuroPlusMed/ [accessed 28th of November 2017].
3.
RigatM., BonetM.A., GarciaS., GarnatjeT., VallèsJ. (2009) Ethnobotany of food plants in the high river Ter valley (Pyrenees, Catalonia, Iberian Peninsula): Non-crop food vascular plants and crop food plants with medicinal properties. Ecology of Food and Nutrition, 48, 303–326.
4.
ZidornC. (2008) Sesquiterpene lactones and their precursors as chemosystematic markers in the tribe Cichorieae of the Asteraceae. Phytochemistry, 69, 2270–2296.
5.
ZidornC., DirschV.M., RüngelerP., SosaS., Della LoggiaR., MerfortI., PahlH.L., VollmarA.M., StuppnerH. (1999) Anti-inflammatory activities of hypocretenolides from Leontodon hispidus. Planta Medica, 65, 704–708.
6.
ZidornC., StuppnerH., TiefenthalerM., KonwalinkaG. (1999) Cytotoxic activities of hypocretenolides from Leontodon hispidus. Journal of Natural Products, 62, 984–987.
7.
ZidornC., StuppnerH. (2001) Chemosystematics of taxa from the Leontodon section Oporinia. Biochemical Systematics and Ecology, 29, 827–837.
8.
SareedenchaiV., ZidornC. (2010) Flavonoids as chemosystematic markers in the tribe Cichorieae of the Asteraceae. Biochemical Systematics and Ecology, 38, 935–957.
9.
MichalskaK., StojakowskaA., MalarzJ., DoležalováI., LebedaA., KisielW. (2009) Systematic implications of sesquiterpene lactones in Lactuca species. Biochemical Systematics and Ecology, 37, 174–179.
10.
MichalskaK., SznelerE., KisielW. (2013) Sesquiterpene lactones from Lactuca canadensis and their chemotaxonomic significance. Phytochemistry, 90, 90–94.
11.
Coronado-AcevesE.W., VelázquezC., Robles-ZepedaR.E., Jiménez-EstradaM., Hernández-MartínezJ., Gálvez-RuizJ.C., Garibay-EscobarA. (2016) Reynisin and santamarine: two sesquiterpene lactones from Ambrosia confertiflora with bactericidal activity against clinical strains of Mycobacterium tuberculosis. Pharmaceutical Biology, 54, 2623–2628.
12.
AhmedA.A., GátiT., HusseinT.A., AliA.T., TzakouO.A., CouladisM.A., MabryT.J., TóthG. (2003) Ligustolide A and B, two novel sesquiterpenes with rare skeletons and three 1,10-seco-guaianolide derivatives from Achillea ligustica. Tetrahedron, 59, 3729–3735.