The radical scavenging assay-guided fractionation of the root extract of Cnidoscolus souzae resulted in the isolation and identification of a novel bioactive dimeric diterpene with an ether linkage which has been designated as dinimbidiol ether (2). Evaluation of the antioxidant activity using the DPPH reduction assay showed that 2 is the most active metabolite in the crude extract of the plant.
Zapata-EstrellaHE, Sánchez-PardenillaAD, García-SosaK, Escalante-ErosaF, de Campos-BuzziF, Meira-QuintãoNL, Cechinel-FilhoV, Peña-RodríguezLM. (2014) Bioactive metabolites from Acmella pilosa and Cnidoscolus souzae. Natural Product Communications, 9, 1319–1321.
2.
AriharaS, UmeyamaA, BandoS, ImotoS, OnoM, TaniM, YoshikawaK. (2004) A new abietane and two dimeric abietane diterpenes from the black heartwood of Cryptomeria japonica. Chemical and Pharmaceutical Bulletin, 52, 354–358.
3.
SureshG, Suresh BabuK, Suri AppaRao M, Rama SubbaRao V, Ashok YadavP, Lakshma NayakV, SistlaRamakrishna (2011) Premnalatifolin A, a novel dimeric diterpene from Premna latifolia Roxb. Tetrahedron Letters, 52, 5016–5019.
GalliB, GasparriniF, LanzottiV, MisitiD, RiccioR, VillaniC, Guan-fuH, Zhong-wuM, Wan-fenY. (1999).. Grandione, a new heptacyclic dimeric diterpene from Torreya grandis Fort. Tetrahedron, 55, 11385–11394.
6.
KuoY-H, YuM-T. (1996) Diterpenes from the heartwood of Juniperus formosana Hay var. concolor Hay. Chemical and Pharmaceutical Bulletin, 44, 1431–1435.
7.
TakahashiJA, BoaventuraMAD, BaymaJC, OliveraAB. (1995) Frutoic acid, a dimeric kaurane diterpene from Xylopia frutescens. Phytochemistry, 40, 607–609.
8.
NiZ-Y, WuY-B, DongM, ZhangM-L, WangY-F, SauriolF, ZhangM, QingS, GuY-C, KiyotaH, CongB (2011) Diabietane ether, a new dimeric abietane with an ether linkage from Taxus cuspidata needles. Zeitschrift für Naturforschung, 66B, 1083–1086.
9.
YoshidaT, ToyotaM, AsakawaY. (1997) Scapaundulins A and B, two novel dimeric labdane diterpenoids, and related compounds from the Japanase liverwort Scapania undulata (L.) Dum. Tetrahedron Letters, 38, 1975–1978.
