This account describes methods for synthesizing natural ellagitannins. The ellagitannins, a class of polyphenols, has a wide variety of chemical structures and biological activities. Here, we focus on three topics, which are the synthesis of the hexahydroxydiphenoyl group, construction of the hexahydroxydiphenoyl bridge, and synthesis of C–O digallates. The hexahydroxydiphenoyl group and the C–O digallates are C–C and C–O coupled galloyl groups, respectively, both group of which are the two major components of ellagitannins. By combining methods described in this account, many ellagitannins might be synthesized.
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