Microwave Assisted Synthesis of p -Methoxycinnamamides and p -Methoxy-β-nitrostyrenes from Ethyl p -methoxycinnamate and Screening their Anti-inflammatory Activity
Free accessResearch articleFirst published online August, 2017
Microwave Assisted Synthesis of p -Methoxycinnamamides and p -Methoxy-β-nitrostyrenes from Ethyl p -methoxycinnamate and Screening their Anti-inflammatory Activity
A new modification reaction of ethyl p-methoxycinnamate (1) to afford a series of p-methoxycinnamamide and p-methoxy-β-nitrostyrene has been developed by using the assistance of the unmodified microwave oven. The synthesized compounds were characterized by using various spectroscopic techniques and furthermore screened for their anti-inflammatory activity by using anti-denaturation of heat bovine serum albumin (BSA) method. The result of bioassay indicated that p-methoxycinnamamide derivatives and p-methoxy-β-nitrostyrenes showed interesting anti-inflammatory activity.
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