Sclareol has been employed as starting material for the synthesis of several advanced intermediates towards the synthesis of highly ring B oxygenated labdanes. Dinorlabdanes 6,7,8,9-tetraoxygenated with 6,7-dioxygenated functionalities with α-cis or β-cis dispositions, have been prepared and can be used for forskolin or analogues synthesis.
MarcosIS, CastañedaL, BasabeP, DíezD, UronesJG. (2009) Synthesis of (+)-leopersin D. Tetrahedron, 65, 9256–9263
2.
MarcosIS, CastañedaL, BasabeP, DíezD, UronesJG. (2008) Synthesis of sibiricinone A, sibiricinone B and leoheterin. Tetrahedron, 64, 10860–10866
3.
MarcosIS, CastañedaL, BasabeP, DíezD, UronesJG. (2008) Synthetic studies to highly functionalised B ring labdanes. Tetrahedron, 64, 8815–8829.
4.
MarcosIS, CastanedaL, BasabeP, DiezD, UronesJG. (2012) Labdane Diterpenes with Highly Functionalized B Rings. Mini-Reviews in Organic Chemistry, 9, 54–86
5.
SavonaG, BrunoM, ServettazO, RodríguezB. (1984) Galeuterone and pregaleuterone, labdane diterpenoids from Galeopsis reuteri. Phytochemistry, 23, 2958–2959
6.
TasdemirD, SticherO, ÇalisI, LindenA. (1997) Further Labdane Diterpenoids Isolated from Leonurus persicus. Journal of Natural Products, 60, 874–879.
7.
BhatSV, DohadwallaAN, BajwaBS, DadkarNK, DornauerH, De SouzaNJ. (1983) The antihypertensive and positive inotropic diterpene forskolin: effects of structural modifications on its activity. Journal of Medicinal Chemistry, 26, 486–492.
8.
ErhardtPW. (1987) In search of the digitalis replacement. Journal of Medicinal Chemistry, 30, 231–237.
9.
LicheyI, FriedrichT, PriesnitzM, BiaminoG, UsingerP, HuckaufH. (1984) Effect of forskolin on methacholine-induced bronchoconstriction in extrinsic asthmatics. Lancet, 2, 167.
10.
CaprioliJ. (1985) The pathogenesis and medical management of glaucoma. Drug Development Research, 6, 193–215.
11.
LaurenzaA, SutkowskiEM, SeamonKB. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?Trends in Pharmacological Sciences, 10, 442–447
12.
AbbadiM, MorinC. (1999) On the analogy between forskolin and D-glucose. Bioorganic & Medicinal Chemistry Letters, 9, 1779–1782
13.
SeamonK, DalyJW. (1981) Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. Journal of Biological Chemistry, 256, 9799–9801
14.
SeamonKB, PadgettW, DalyJW. (1981) Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proceedings of the National Academy of Sciences of the United States of America, 78, 3363–3367
15.
BenderJL, WolfLG, NeerEJ. (1984) Interaction of forskolin with resolved adenylate cyclase components. Advances in Cyclic Nucleotide and Protein Phosphorylation Research, 17, 101–109
16.
DalyJW. (1984) Forskolin, adenylate cyclase, and cell physiology: an overview. Advances in Cyclic Nucleotide and Protein Phosphorylation Research, 17, 81–89
17.
SeamonKB, WetzelB. (1984) Interaction of forskolin with dually regulated adenylate cyclase. Advances in Cyclic Nucleotide and Protein Phosphorylation Research, 17, 91–99.
18.
DelpechB, CalvoD, LettR. (1996) Total synthesis of forskolin — Part I. Tetrahedron Letters, 37, 1015–1018
19.
DelpechB, CalvoD, LettR. (1996) Total synthesis of forskolin — Part II. Tetrahedron Letters, 37, 1019–1022
20.
CalvoD, PortM, DelpechB, LettR. (1996) Total synthesis of forskolin — Part III studies related to an asymmetric synthesis. Tetrahedron Letters, 37, 1023–1024
21.
ZieglerFE, JaynesBH, SaindaneMT. (1987) A synthetic route to forskolin. Journal of the American Chemical Society, 109, 8115–8116
22.
HashimotoS, SakataS, SonegawaM, IkegamiS. (1988) A total synthesis of (.+-.)-forskolin. Journal of the American Chemical Society, 110, 3670–3672
23.
CoreyEJ, Da Silva JardineP. (1989) A short and efficient enantioselective route to a key intermediate for the total synthesis of forskolin. Tetrahedron Letters, 30, 7297–7300
24.
CoreyEJ, JardinePdS, RohloffJC. (1988) Total synthesis of (.+-.)-forskolin. Journal of the American Chemical Society, 110, 3672–3673.
25.
HagiwaraH, TakeuchiF, KudouM, HoshiT, SuzukiT, HashimotoT, AsakawaY. (2006) Synthetic Transformation of Ptychantin into Forskolin and 1,9-Dideoxyforskolin. The Journal of Organic Chemistry, 71, 4619–4624.
26.
MarcosIS, HernándezFA, SexmeroMJ, DíezD, BasabeP, PedreroAB, GarcíaN, SanzF, UronesJG. (2002) Synthesis and absolute configuration of (-)-chettaphanin II. Tetrahedron Letters, 43, 1243–1245
27.
OliverSF, HögenauerK, SimicO, AntonelloA, SmithMD, LeySV. (2003) A Route to the Thapsigargins from (S)-Carvone Providing a Substrate-Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F. Angewandte Chemie International Edition, 42, 5996–6000.
28.
PaquetteLA, WangH-L. (1996) Stereocontrolled Synthesis of ent-Grindelic Acid. A Useful Example of Diastereofacial Guidance in an Oxonium Ion-Initiated Pinacolic Ring Expansion. The Journal of Organic Chemistry, 61, 5352–5357