One new gentisyl alcohol derivative and seven known compounds were isolated from the culture of Penicillium sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1, 4, and 6 inhibited Bacillus subtilis, Staphylococcus aureus, and Escherichia coli with MICs of 32–128 μg/mL.
ChenCX, ZhouJ, ZhangYT, ZhaoYY. (1990) Steroids saponins of aerial parts of Paris polyphylla var. yunnanensis. Acta Botanica Yunnanica, 12, 323–329.
2.
MatsudaH, PongpiriyadachaY, MorikawaT, KishiA, KataokaS, YoshikawaM. (2003) Protective effects of steroid saponins from Paris polyphylla var. yunnanensi on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action. Bioorganic & Medicinal Chemistry Letters, 13, 1101–1106.
3.
HuangY, ZhaoJ, ZhouL, WangM, WangJ, LiX, ChenQ. (2009) Antimicrobial compounds from the endophytic fungus Fusarium sp. Ppf4 isolated from the medicinal plant Paris polyphylla var. yunnanensis. Natural Product Communications, 4, 1455–1458;
4.
ZhaoJ, ShanT, HuangY, LiuX, GaoX, WangM, JiangW, ZhouL. (2009) Chemical composition and in vitro antimicrobial activity of the volatile oils from Gliomastix murorum and Pichia guilliermondii, two endophytic fungi in Paris polyphylla var. yunnanensis. Natural Product Communications, 4, 1491–1496;
5.
ZhangY, ZhaoJ, WangJ, ShanT, MouY, ZhouL, WangJ. (2011) Chemical composition and antimicrobial activity of the volatile oil from Fusarium tricinctum, the endophytic fungus in Paris polyphylla var. yunnanensis. Natural Product Communications, 6, 1759–1762;
6.
YangY, YangSC, ZhaoJ, UdikeriS, LiuT. (2015) Microbial diversity in Paris polyphylla var. yunnanensis rhizomes of varying ages. Genetics and Molecular Research: GMR, 14, 17612–17621.
7.
SekiguchiJ, ShimamotoT, YamadaY, GaucherGM. (1983) Patulin biosynthesis: enzymatic and nonenzymatic transformations of the mycotoxin (E)-ascladiol. Applied and Environmental Microbiology, 45, 1939–1942.
8.
LiuYF, GanML, YangYH, LiuYS, GuanY, XiaoCL. (2014) Antibacterial metabolites from Penicillium sp. I09F 484. Chinese Pharmaceutical Journal, 49, 632–635.
9.
ChenLJ, ShiHZ, HuKF. (2010) Antifungal activity and chemical component analysis of volatile compounds from Penicillium vulpinum. Journal of Fungal Research, 8, 231–233, 244.
10.
LiW, YangXQ, YangYB, QinSH, LiQL, ZhaoLX, DingZT. (2015) A new natural nucleotide and other antibacterial metabolites from an endophytic Nocardia sp. Natural Product Research, 29, 132–136.
11.
MiaoCP, HuJ, ZhaiYZ, SongF, XuanQC, ChenYW, WuSH. (2012) Identification and secondary metabolites of endophytic fungus PR20 from Paeonia delavayi. Natural Product Research and Development, 24, 1339–1342.
12.
ChenL, FangYC, ZhuTJ, GuQQ, ZhuWM. (2008) Gentisyl alcohol derivatives from the marine-derived fungus Penicillium terrestre. Journal of Natural Products, 71, 66–70.
