Phytochemical study of Gentianella azurea (Bunge) Holub (Gentianaceae) collected in Buryatia Republic (Russian Federation) resulted in the isolation of twenty-one compounds including bellidifolin, bellidin, isobellidifolin, norswertianolin, isobellidifolin-8-O-β-D-glucopyranoside, orientin, cynaroside, cosmosiin, apigenin, 4′-O-caffeoylswertiamarin, swertiamarin-6′-O-β-D-glucopyranoside and sweroside, firstly detected in this species. The extracts and individual compounds were shown to possess antioxidant and anticholinesterase potential.
AseevaTA, DashievDB, DashievAD, NikolaevSM, SurkovaNA, ChekhirovaGV, YurinaTA. (2008) Tibetan Medicine of Buryats. SO RAN, Novosibirsk. 217–264. (in Russian).
2.
PurevO, OyunKh, OdontuyaG, TankhaevaLM, NikolaevaGG, KhanKM, Ali ShanST, VoelterW. (2002) Isolation and structure elucidation of two xanthones from Gentiana azurium Bunge (Fam. Gentianaceae). Zeitschrift für Naturforschung, 57B, 331–334;
3.
ZhangY, YangC. (1994) Chemical studies on Gentianella azurea, a Tibetan medicinal plant. Acta Botanica Yunnanica, 16, 401–406;
4.
ShiK, WangY, JiangQ, LiaoZ. (2010) Chemical constituents of Gentianella azurea. Chinese Journal of Natural Medicine, 8, 425–427.
5.
OlennikovDN. (2013) Chemical investigation of Anagallidium dichotomum and anticholinesterase activity of its constituents. Chemistry of Natural Compounds, 49, 1137–1139;
6.
OlennikovDN, KashchenkoNI, ChirikovaNK, TankhaevaLM. (2015) Iridoids and flavonoids of four Siberian gentians: Chemical profile and gastric stimulatory effect. Molecules, 20, 19172–19188;
7.
OlennikovDN, KashchenkoNI, ChirikovaNK, KoryakinaLP, VladimirovLN. (2015) Bitter gentian teas: Nutritional and phytochemical profiles, polysaccharide characterisation and bioactivity. Molecules, 20, 20014–20030;
8.
OlennikovDN, ChirikovaNK. (2016) Algidisides I and II, new iridoids glycosides from Gentiana algida. Chemistry of Natural Compounds, 52, 637–641.
Di GiovanniS, BorlozA, UrbainA, MarstonA, HostettmannK, CarruptPA, ReistM. (2008) In vitro screening assays to identify natural or synthetic acetylcholinesterase inhibitors: Thin layer chromatography versus microplate methods. European Journal of Pharmaceutical Sciences, 33, 109–119.
