Two new phenolic glycosides, physangulosides A and B (1 and 2), were isolated from the whole plant of Physalis angulata. Their chemical structures were determined by mean of HR-ESI-MS, 1D, and 2D-NMR spectra. Both of the compounds showed weak protection against hydrogen peroxide induced hepatocytes damage.
LimaM.S., EvangelistaA.F., SantosGgld, RibeiroI.M., TomassiniT.C.B., Pereira SoaresM.B., VillarrealC.F. (2014) Antinociceptive properties of physalins from Physalis angulata. Journal of Natural Products, 77, 2397–2403.
2.
(a) BastosG.N.T., SilveiraA.J.A., SalgadoC.G., Picanço-DinizD.L.W., do NascimentoJ.L.M. (2008) Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways. Journal of Ethnopharmacology, 118, 246–251; (b) Jin Z, Mashuta MS, Stolowich NJ, Vaisberg AJ, Stivers NS, Bates PJ, Lewis WH, Hammond GB. (2012) Physangulidines A, B, and C: Three new antiproliferative withanolides from Physalis angulata L. Organic Letters, 14, 1230–1233; (c) Kuo PC, Kuo TH, Damu AG, Su CR, Lee EJ, Wu TS, Shu R, Chen CM, Bastow KF, Chen TH, Lee KH. (2006) Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata. Organic Letters, 8, 2953–2956.
3.
KiemP.V., ThuV.K., YenP.H., NhiemN.X., TungN.H., CuongN.X., MinhC.V., HuongH.T., HyunJ.H., KangH.K., KimY.H. (2009) New triterpenoid saponins from Glochidion eriocarpum and their cytotoxic activity. Chemical and Pharmaceutical Bulletin, 57, 102–105.
