During the search for bioactive secondary metabolites, thelepalmatins A and B (1 and 2) were isolated from the fresh fruiting bodies of Thelephora palmata, together with four known compounds (3-6). Their structures were elucidated using MS analyses, and extensive 2D-heteronuclear NMR data interpretation. Compounds 3, 4 and 6 showed antimicrobial activities against Staphylococcus aureus and Bacillus subtilis with MIC values of 21.7-70.4 μM.
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2.
UmeyamaA, TakahashiK, GrudniewskaA, ShimizuM, HayashiS, KatoM, OkamotoY, SuenagaM, BanS, KumadaT, IshiyamaA, IwatsukiM, OtoguroK, Ōmura S, HashimotoT. (2014) In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832. The Journal of Antibiotics, 67, 163-167
3.
UmeyamaA, OhtaC, ShinoY, OkadaM, NakamuraY, HamagakiT, ImagawaH, SuenagaM, TanakaM, IshiyamaA, IwatsukiK, OtoguroM, Ōmura S, HashimotoT. (2014) Three lanostane triterpenoids with antitrypanosomal activity from the fruiting body of Hexagonia tenuis. Tetrahedron, 70, 8312-8315.
4.
RadulozicN, QuangD-N, HashimotoT, AsakawaY. (2005) p-Terphenyl derivatives from the inedible mushroom Thelephora terrestris. Phytochemistry, 66, 1052–1059
5.
XieC, KoshinoH, EsumiY, OnoseJ, YoshikawaK, AbeN. (2006) Vialinin B, a novel potent inhibitor of TNF-α production, isolated from an edible mushroom, Thelephora vialis. Bioorganic & Medicinal Chemistry Letters, 16, 5424–5426
6.
HuL, GaoJ-M, LiuJ.-K. (2001) Unusual poly(phenylacetyloxy)-substituted 1,1′: 4′,1″-terphenyl derivatives from fruiting bodies of the Basidiomycete Thelephora ganbajun. Helvetica Chimica Acta.84, 3342–3349.
7.
FukudaT, NagaiK, TomodaH. (2012) (±)-Tylopilusins, diphenolic metabolites from the fruiting bodies of Tylopilus eximius. Journal of Natural Products, 75, 2228–2231;
8.
TomodaH, FukudaT, KoyamaN. (2013) Tylopilusins having inhibitory activity on yellow pigment formation by MRSA, their manufacture from Tylopilus eximius, and their use for drugs. Japan Kokai Tokkyo Koho. JP 2013023448 A 20130204.
