Dipasperoside B (1), isolated from the root of Dipsacus asper, was determined to be a first example of naturally occurring iridoid glucoside trimer with an unusual skeleton featuring oxaloacetic acid derived moiety coupled with a secoiridoid nucleus in the central part, on the basis of spectroscopic data. Dipasperoside B (1) revealed the inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cell line, with an IC50 value of 21.3 μM, identical to a positive control, NG-monomethyl-L-arginine (L-NMMA, IC50 22.6 μM), without any significant cytotoxicity.
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