Two New Compounds from the Leaves of Glochidion obliquum

Abstract

Using combined chromatographic methods, two new compounds, 6β,9β:9,13-diepoxymegastig-4-en-3β-ol (1), 5α,6α-epoxy D:C-friedoolean-8-en-3β-ol (2) were isolated from the methanol extract of the leaves of Glochidion obliquum Decne. Their structures were elucidated by 1D- and 2D-NMR spectra and in comparison with those reported in the literature.

Keywords

Glochidion obliquum 6β,9β:9,13-Diepoxymegastig-4-en-3β-ol 5α,6α-Epoxy D:C-friedoolean-8-en-3β-ol

References

Chi

V.V.

(2012) The Dictionary of Medicinal Plants in Vietnam. Medical Publishing House: Hanoi, 2, 697.

Kiem

P.V.

, Thu

V.K.

, Yen

P.H.

, Nhiem

N.X.

, Tung

N.H.

, Cuong

N.X.

, Minh

C.V.

, Huong

H.T.

, Hyun

J.H.

, Kang

H.K.

, Kim

Y.H.

(2009) New triterpenoid saponins from Glochidion eriocarpum and their cytotoxic activity. Chemical and Pharmaceutical Bulletin, 57, 102–105.

Thang

T.D.

, Kuo

P.C.

, Yu

C.S.

, Shen

Y.C.

, Hoa le

T.M.

, Van Thanh

, Kuo

Y.H.

, Yang

M.L.

, Wu

T.S.

(2011) Chemical constituents of the leaves of Glochidion obliquum and their bioactivity. Archives of Pharmacal Research, 34, 383–389.

Näf

, Velluz

, Decorzant

, Näf

(1991) Structure and synthesis of two novel ionone-type compounds identified in quince brandy (Cydonia oblonga Mil.). Tetrahedron Letters, 32, 753–756.

Faure

, Gaydou

E.M.

, Wollenweber

(1991) Application of inverse-detected two-dimensional heteronuclear-correlated NMR spectroscopy to the complete carbon- 13 assignment of isomultiflorenyl acetate. Journal of Natural Products, 54, 1564–1569.

Dračínský

, Hybelbauerová

, Sejbal

, Buděšínský

(2006) Preparation and conformational study of B-ring substituted lupane derivatives. Collection of Czechoslovak Chemical Communications, 71, 1131–1160.

Fuchino

, Satoh

, Tanaka

(1995) Chemical evaluation of Betula species in Japan. I. Constituents of Betula ermanii. Chemical and Pharmaceutical Bulletin, 43, 1937–1942; (b) Puapairoj P, Naengchomnong W, Kijjoa A, Pinto MM, Pedro M, Nascimento MS, Silva AM, Herz W. (2005) Cytotoxic activity of lupane-type triterpenes from Glochidion sphaerogynum and Glochidion eriocarpum two of which induce apoptosis. Planta Medica, 71, 208–213.

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