The essential oil obtained by hydrodistillation from the fresh fruits of Xylopia laevigata was analyzed by gas chromatography using a flame ionization detector (GC–FID) coupled to a mass spectrometer (GC–MS). Monoterpenes predominated, forming 95.0% of the total essential oil. The major constituents identified were limonene (56.2%), α-pinene (28.0%), and β-pinene (5.5%). Cytotoxic activity against tumor cell lines and non-tumor cells was also investigated; however, neither the essential oil nor its major constituents evaluated presented any cytotoxic activity (IC50 > 25.0 μg mL−1).
CostaEV, SilvaTB, MenezesLRA, RibeiroLHG, GadelhaFR, CarvalhoJE, SouzaLMB, SilvaMAN, SiqueiraCAT, SalvadorMJ. (2013) Biological activities of the essential oil from the leaves of Xylopia laevigata (Annonaceae). Journal of Essential Oil Research, 14, 179–185.
4.
SilvaTB, MenezesLRA, SampaioMFC, MeiraCS, GuimaraesET, SoaresMBP, PrataAPN, NogueiraPCL, CostaEV. (2013) Chemical composition and anti-Trypanosoma cruzi activity of essential oils obtained from leaves of Xylopia frutescens and X. laevigata (Annonaceae). Natural Product Communications, 8, 403–406.
5.
QueirozJCC, AntoniolliAR, Quintans-JúniorLJ, BritoRG, BarretoRSS, CostaEV, SilvaTB, PrataAPN, LuccaWJr., AlmeidaJRGS, LimaJT, QuintansJSS. (2014) Evaluation of the anti-inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models. The Scientific World Journal, 2014, 1–11.
6.
CostaEV, DutraLM, NepelA, BarisonA. (2013) Isoquinoline alkaloids from the leaves of Xylopia laevigata (Annonaceae). Biochemical Systematics and Ecology, 51, 331–334.
7.
van den DoolH, KratzPD. (1963) A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography. Journal of Chromatography, 11, 463–471;
8.
AdamsRP. (2007) Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry. 4th ed. Allured Publ. Corp., Carol Stream, IL.
9.
AhmedSA, GogalRM, WalshJE. (1994) A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes an alternative to [3H] thymidine incorporation assay. Journal of Immunological Methods, 170, 211–224.
10.
RodriguesACBC, BomfimLM, NevesSP, MenezesLRA, DiasRB, SoaresMBP, PrataAPN, RochaCAG, CostaEV, BezerraDP. (2015) Antitumor properties of the essential oil from the leaves of Duguetia gardneriana. Planta Medica, 81, 798–803.
