One new bifuran derivative (1), together with fourteen known compounds, were isolated from Cordyceps cicadae X. Q. Shing. The known compounds included nine nucleosides, uracil (2), uridine (3), 2′-deoxyuridine (4), 2′-deoxyinosine (5), guanosine (6), 2′-deoxyguanosine (7), thymidine (8), adenosine (9), and 2′-deoxyadenosine (10); three amino acids tryptophan (11), phenylalanine (12), and tyrosine (13); and two dopamine analogues N-acetylnoradrenaline (14) and its dimer, trans–2-(3′,4′-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2″-amino-ethylene)-1,4-benzodioxane (15). Their structures were decisively elucidated by spectroscopic analysis, including 1D and 2D NMR techniques.
ZengWB, YuH, GeF, YangJY, ChenZH, WangYB, DaiYD, AdamsA. (2014) Distribution of nucleosides in populations of Cordyceps cicadae. Molecules, 19, 6123–6141.
2.
Nanjing University of Chinese Medicine. (2006) The Dictionary of Chinese Traditional Medicine. Shanghai Press of Science and Technology, Shanghai, 3597–3598.
3.
KihoT, ItoM, NagaiK, HaraC, UkaiS. (1988) Polysaccharides in fungi. XXII. a water soluble polysaccharide from the alkaline extract of the insect-body portion of Chan hua (fungus: Cordyceps cicadae). Chemical & Pharmaceutical Bulletin, 36, 3032–3037;
4.
UkaiS, MatsuuraS, HaraC, KihoT, HiroseK. (1982) Structure of a new galactomannan from the ascocarps of Cordyceps cicadae Shing. Carbohydrate Research, 101, 109–116;
5.
FujitaT, InoueK, YamamotoS, IkumotoT, SasakiS, ToyamaR, ChibaK, HoshinoY, OkumotoT. (1994) Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite. Journal of Antibiotics, 47, 208–215;
6.
KuoYC, LinLC, DonMJ, LiaoHF, TsaiYP, LeeGH, ChouCJ. (2002) Cyclodepsipeptide and dioxomorpholine derivatives isolated from the insect-body portion of the fungus Cordyceps cicadae. Journal of Chinese Medicine, 13, 209–219;
7.
WangJ, ZhangDM, JiaJF, PengQL, TianHY, WangL, YeWC. (2014) Cyclodepsipeptides from the ascocarps and insect-body portions of fungus Cordyceps cicadae. Fitoterapia, 97, 23–27.
8.
FuruyaT, HirotaniM, MatsuzawaM. (1983) N6-(2-hydroxyethyl) adenosine, a biologically active compound from cultured mycelia of Cordyceps and Isaria species. Phytochemistry, 22, 2509–2512;
9.
ZhangSW, XuanLJ. (2007) Five aromatics bearing a 4-O-methylglucose unit from Cordyceps cicadae. Helvetica Chimica Acta, 90, 404–410;
10.
ZhangSW, XuanLJ. (2008) Cyclopentenone and furan derivative from the mycelia of Cordyceps cicadae. Journal of Antibiotics, 61, 43–45.
11.
JiangK, BaiJQ, ChangJ, TanJJ, QuSJ, LuoHF, TanCH, ZhuDY. (2014) Three new 24-nortriterpenoids from the roots of Ilex asprella. Helvetica Chimica Acta, 97, 64–69;
12.
ChangJ, ChuZB, SongJ, JinL, SunX. (2015) Two novel isoquinoline alkaloids from the seedling of Corydalis decumbens. Tetrahedron Letters, 56, 225–228.
13.
SongMC, YangHJ, JeongTS, KimKT, BaekNI. (2008) Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation. Archives of Pharmacal Research, 31, 573–578.
14.
LiuJ, XuJ, ZhaoXJ, GaoWY, ZhangSZ, GuoYQ. (2010) A new heterocyclic compound from Cyathula officinalis Kuan. Chinese Chemical Letters, 21, 70–72.
