One new diterpenoid alkaloid, pubescensine (1), along with nine known diterpenoid alkaloids (2–10) were isolated from the roots of Aconitum soongaricum var. pubescens. Their structures were elucidated by spectroscopic analyses and comparison with previously reported data. All the compounds were evaluated for their antifeedant activities. The aconitine-type diterpenoid alkaloids (1–6) showed considerably potent antifeedant activity (EC50 < 1 mg/cm2), while the activities of napelline-type diterpenoid alkaloids (compds. 7, 9 and 10) were not significant (EC50 > 50 mg/cm2).
DzhakhangirovFN, SultankhodzhaevMN, TashkhodzhaevB, SalimovBT. (1997) Diterpenoid alkaloids as a new class of antiarrthythmic agents. Structure-activity relationship. Chemistry of Natural Compounds, 33, 190–202.
2.
AmeriA. (1998) The effects of aconitum alkaloids on the central nervous system. Progress in Neurobiology, 56, 211–235.
LiuZL, CaoJ, ZhangHM, LinLL, LiuHJ, DuSS, ZhouLG, DengZW. (2011) Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. Journal of Agricultural and Food Chemistry, 59, 3701–3706.
6.
ReinaM, González-ColomaA. (2007) Structural diversity and defensive properties of diterpenoid alkaloids. Phytochemistry Reviews, 6, 81–95.
7.
PelletierSW, ModyNV, JoshiBS, SchrammLC. (1984) Alkaloids: Chemical and Biological Perspectives, Vol. 2, PelletierSW. (Ed.). Wiley, New York, 205–210.
8.
PelletierW, ModyNV, KatsuiN. (1977) The structures of sachaconitine and isodelphinine from Aconitum miyabei Nakai. Tetrahedron Letters, 46, 4027–4030.
9.
HanumanJB, KatzA. (1993) Isolation and identification of four norditerpenoid alkaloids from processed and unprocessed root tubers of Aconitum ferox. Journal of Natural Products, 56, 801–809.
10.
TakayamaH, HasegawaS, SakaiS, HaginiwaJ, OkamotoT. (1981) Structure elucidation of a new aconite alkaloid, 15-α-hydroxyneolin. Chemical & Pharmaceutical Bulletin, 29, 3078–3080.
11.
Tel'novVA, VaisovZM, YunusovMS, GorelovaAP. (1992) Alkaloids of the cultivated species Aconitum tauricum. Chemistry of Natural Compounds, 28, 91–94.
12.
ShimSH, KimJS, KangSS, SonKH, BaeKH. (2003) Alkaloidal constituents from Aconitum jaluense. Archives of Pharmacal Research, 26, 709–715.
13.
WiesnerK., ItôS, ValentaZ. (1958) The structure of napelline and songorine. Experientia, 14, 167–169.
14.
FanZC, ZhangZQ. (2008) Molecular and crystal structure of 15-acetylsongorine and songoramine isolated from Aconitum szechenyianum Gay. Structural Chemistry, 19, 413–419.
15.
CsuporD, ForgoP, CsedóK, HohmannJ. (2006) C19 and C20 Diterpene alkaloids from Aconitum toxicum RCHB. Helvetica Chimica Acta, 89, 2981–2986.
16.
ZhapovaTs, SemenovAA. (1993) 12-epi-Napelline and its N-oxide from Aconitum baicalense. Chemistry of Natural Compounds, 29, 791–794.
17.
González-ColomaA, ReinaM, CabreraR, CastaneraP, GutierrezC. (1995) Antifeedant and toxic effects of sesquiterpenes from Senecio palmensis to Colorado potato beetle. Journal of Chemical Ecology, 21, 1255–1270.
18.
González-ColomaA, TerreroD, PeralesA, EscoubasP, FragaBM. (1996) Insect antifeedant ryanodane diterpenes from Persea indica. Journal of Agricultural and Food Chemistry, 44, 296–300.
