Genotoxicity and antigenotoxicity studies of (traditional medicinal) plants are important from a risk assessment point of view and in the search for new medication against, for example, cancer. It is clear yet that attention should be paid to a number of aspects that may influence the outcome of a study and to which often no or insufficient attention is paid. A short overview is given of such aspects that deserve more attention.
ThomsonSA. (2000) South African government genocide and ethnopiracy. The Gaia Research Institute, South Africa.
4.
MarcusDM, GrollmanAP. (2012) The consequences of ineffective regulation of dietary supplements. Archives of Internal Medicine, 172, 1035–1036.
5.
Déciga-CamposM, Rivero-CruzI, Arriaga-AlbaM, Castaňeda-CorralG, Angeles-LópezGE, NavarreteA, MataR. (2007) Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine. Journal of Ethnopharmacology, 110, 334–342.
6.
Mohd-FuatAR, KofiEA, AllanGG. (2007) Mutagenic and cytotoxic properties of three herbal plants from Southeast Asia. Tropical Biomedicine, 24, 49–59.
7.
VerschaeveL, Van StadenJ. (2008) Mutagenic and antimutagenic properties of extracts from South African traditional medicinal plants. Journal of Ethnopharmacology, 119, 575–587.
8.
De Sã FerriraICF, Ferrão VargasVM. (1999) Mutagenicity of medicinal plant extracts in salmonella/microsome assay. Phytotherapy Research, 13, 397–400.
9.
MitscherLA, DrakeS, GollapudiR, HarrisJA, ShankelDM. (1986) Isolation and identification of higher plant agents active in antimutagenic assay systems: Glycyrrhiza glabra. In Antimutagenesis and anticarcinogenesis. ShankelDM, HartmanPF, KadaT, HollaenderA. (Eds). Plenum Press, New York, 153–165.
10.
BhattacharyaS. (2011) Natural antimutagens: A review. Research Journal of Medicinal Plants, 5, 116–126.
11.
AqilF, ZahinM, AhmadI. (2008) Antimutagenic activity of methanolic extracts of four ayurvedic medicinal plants. Indian Journal of Experimental Biology, 46, 668–672.
12.
SłoczyhskaK, PowroźnikB, PękalaE, WaszkielewiczAM. (2014) Antimutagenic compounds and their possible mechanisms of action. Journal of Applied Genetics, 55, 273–285.
OngT, WongWZ, StewartJD, BrockmanHE. (1986) Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures. Mutation Research, 173, 111–115.
18.
Gomes-CarneiroMR, DiasDMM, De-OliveiraACAX, PaumgarttenFJR. (2005) Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay. Mutation Research, 585, 105–112.
19.
FronzaG, CampomenosiP, LannonelR, AbbondandoloA. (1992) The 4-nitroquinoline 1-oxide mutational spectrum in single stranded DNA is characterized by guanine to pyrimidine transversions. Nucleic Acids Research, 20, 1283–1287.
20.
NumoshibaT, DempleB. (1993) Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide. Cancer Research, 53, 3250–3252.
21.
ArimaY, NishigoriC, TakeuchiT, OkaS, MorimotoK, UtaniA, MiyachiY. (2006) 4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species. Toxicological Sciences, 91, 382–392.
22.
von BorstelRC, HigginsJA. (1998) Janus carcinogens and mutagens. Mutation Research, 402, 321–329.
23.
ZeigerE. (2003) Illusions of safety: antimutagens can be mutagens, and anticarcinogens can be carcinogens. Mutation Research, 543, 191–194.
24.
AdlerS, BasketterD, CretonS, PelkonenO, van BenthemJ, ZuangV, AndersenKE, Angers-LoustauA, AptulaA, Bal-PriceA, BenfenatiE, BernauerU, BessemsJ, BoisFY, BoobisA, BrandonE, BremerS, BroschardT, CasatiS, CoeckeS, CorviR, CroninM, DastonG, DekantW, FelterS, GrignardE, Gundert-RemyU, HeinonenT, KimberI, KleinjansJ, KomulainenH, KreilingR, KreysaJ, LeiteSB, LoizouG, MaxwellG, MazzatortaP, MunnS, PfuhlerS, PhrakonkhamP, PiersmaA, PothA, PrietoP, RepettoG, RogiersV, SchoetersG, SchwarzM, SerafimovaR, TähtiH, TestaiE, van DelftJ, van LoverenH, VinkenM, WorthA, ZaldivarJM. (2011) Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Archives of Toxicology, 85, 367–485.
25.
AtesG, DoktorovaTY, PauwelsM, RogiersV. (2014) Retrospective analysis of the mutagenicity/genotoxicity data of the cosmetic ingredients present on the Annexes of the Cosmetic EU legislation (2000–12). Mutagenesis, 29, 115–121.
26.
BikardD, PatelD, Le MetteC, GiorgiV, CamilleriC, BennettMJ, LoudetO. (2009) Divergent evolution of duplicate genes leads to genetic incompatibilities within Arabidopsis thaliana. Science, 323, 623–626.
27.
MurallaR, SweeneyC, StepanskyA, LeustekT, MeinkeD. (2007) Genetic dissection of histidine biosynthesis in Arabidopsis. Plant Physiology, 144, 890–903.
28.
MakhafolaTJ. (2015) The in vitro inhibition of genotoxicity by plant extracts and the isolation and characterization of antimutagenic compounds from Combretum microphyllum (Combretaceae). PhD thesis, University of Pretoria.
29.
ValgasC, Machado de SouzaS, SmâniaEFA, SmâniaAJr. (2007) Screening methods to determine antibacterial activity on natural products. Brazilian Journal of Microbiology, 38, 369–380.
30.
WHO (2004) WHO guidelines on safety monitoring of medicinal plant products in pharmacovigilance systems. Geneva.
31.
OkemA. (2015) Heavy metals in South African medicinal plants with reference to safety, efficacy and quality. PhD thesis, University of Kwazulu-Natal.
32.
CunninghamAB. (1991) Development of a conservative policy on commercially exploited medicinal plants; a case study for Southern Africa. In Conservation of medicinal plant, Proceedings of an international consultation. 21–27 March 1988, AkereleO, HeywoodV, SyngeH. (Eds), Cambridge University Press, Chiang Mai. 337–358.
33.
WilliamsVL, BalkwillK, WitkowskiETF. (2000) Unravelling the commercial market for medicinal plants and plant parts on the Witwatersrand, South Africa, Economic Botany, 54, 310–327.
34.
ReadTR., BellairsSM, MulliganDR, LambD. (2000) Smoke and heat effects on soil seed bank germination for the re-establishment of a native forest community in New South Wales. Austral Ecology, 25, 48–57.
35.
RocheS, KochJ, DixonKW. (1997) Smoke-enhanced seed germination for mine rehabilitation in the south-west of Western Australia. Restoration Ecology, 5, 191–203.
36.
VerschaeveL, MaesJ, LightM, Van StadenJ. (2006) Genetic toxicity testing of 3-methyl-2H-furo[2,3-c]pyran-2-one, an important biologically active compound from plant-derived smoke. Mutation Research, 611, 89–95.
37.
TrinhC, GevaertL, KohoutL, Van StadenJ, VerschaeveL. (2010) Genotoxicity evaluation of two kinds of smoke water and 3,7-dimethyl-2H-furo[2,3-c]pyran-2-one. Journal of Applied Toxicology, 30, 596–602.
38.
LightME, AnthonissenR, MaesA, VerschaeveL, PoštadM, Van StadenJ. (2015) Genotoxicity testing of 3,4,5-trimethylfuran-2(5H)-one, a compound from plant-derived smoke with germination inhibitory activity. Mutation Research, 778, 1–5.
39.
ScottBR, SparrowAH, SchwemmerSS, SchairerLA. (1978) Plant metabolic activation of 1,2 dibromoethane (EDB) to a mutagen of greater potency. Mutation Research, 40, 203–212.
40.
vd TrenckTH, SandermannHJr. (1980) Oxygenation of benzo[a]pyrene by plant microsomal fractions. FEBS Letters, 119, 227–231.
41.
HigashiK, NakashimaK, KarasakiY, FukunagaM, MisuguchiY. (1981) Activation of benzo[a]pyrene by microsomes of higher plant tissues and their mutagenicity. Biochemistry International, 2, 373–380.
42.
TakehisaS, KanayaN. (1983) A comparison of Vicia faba-root S10 and rat-liver S9 activation of ethanol, maleic hydrazide and cyclophosphamide as measured by sister-chromatid exchange induction in Chinese hamster ovary cells. Mutation Research, 125, 145–151.
