Sesquiterpenes from the Vietnamese Marine Sponge Dysidea Fragilis

Abstract

Two new sesquiterpenes, named dysinidins A-B (3, 4) along with two known sesquiterpenes, furodysinin lactone (1) and O-methyl furodysinin lactone (2), were isolated from the Vietnamese marine sponge Dysidea fragilis. Their structures were determined by 1D- and 2D-NMR spectroscopies and HR ESI MS, as well as by comparison with reported literature data. None of compounds showed inhibitory growth of human lung cancer cell lines, A-549 and H-1975 (IC₅₀ > 30μM).

Keywords

Dysidea fragilis Dysideidae Dysinidin A Dysinidin B Sesquiterpene

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