Three new isoflavonoid glycosides (1, 5, and 9) and 10 known compounds (2–4, 6–8, and 10–13) were isolated from the underground parts of Iris florentina (Iridaceae). The structures of the new compounds were determined based on extensive spectroscopic data and the results of hydrolytic cleavage. The isolated compounds and the aglycones were evaluated for cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 12 induced apoptotic cell death in the HL-60 cells.
HorinakaA. (1988). In The Grand Dictionary of Horticulture. Vol. 1, TsukamotoY. (Ed). Shogakukan, Tokyo, 4.
2.
KrickW, MarnerFJ, JeaniceL. (1983) Isolation and structure determination of the precursors of α- and γ-irone and homologous compounds from Iris pallida and Iris florentina. Zeitschrift für Naturforschung C, 38c, 179–184.
3.
TsukidaK, SaikiK, ItoM. (1973) New isoflavone glycosides from Iris florentina. Phytochemistry, 12, 2318–2319.
4.
FujitaM, InoueT. (1982) Studies on the constituents of Iris florentina L. II. C-Glucosides of xantones and flavones from the leaves. Chemical and Pharmaceutical Bulletin, 30, 2342–2348.
5.
Atta-urR, NasimS, BaigI, OrhanI, SenerB, AyanogluF, ChoudharyMI. (2003) Isoflavonoid glycosides from the rhizomes of Iris germanica. Helvetica Chimica Acta, 86, 3354–3362.
6.
Atta-urR, NasimS, BaigI, OrhanI, SenerB, AyanogluF, ChoudharyMI. (2002) Isoflavonoid glycosides from the rhizomes of Iris germanica. Chemical and Pharmaceutical Bulletin, 50, 1100–1102.
7.
AliAA, El-EmaryNA, El-MoghaziMA, DarwishFM, FrahmAW. (1983) Three isoflavonoids from Iris germanica. Phytochemisry, 22, 2061–2063.
8.
ArisawaM, MoritaN, KondoY, TakeomtoT. (1973) The constituents of Iris florentina L. (3) Structure of irisxanthone, a new C-glucosylxanthone. Chemical and Pharmaceutical Bulletin, 21, 2562–2565.
9.
RanconS, ChaboudA, DarbourN, ComteG, BayetC, SimonPN, RaynaudJ, Di PietroA, CabalionP, BarronD. (2001) Natural and synthetic benzophenones: interaction with the cytosolic binding domain of P-glycoprotein. Phytochemistry, 57, 553–557.
10.
QinghuaS, AilingS, RenminL. (2006) Preparative isolation and purification of four compounds from the Chinese medicinal herb Rhizoma Anemarrhenae by high-speed counter-current chromatography. Journal of Chromatography A, 1104, 69–74.
11.
ArisawaM, MoritaN, KondoY, TakeomtoT. (1973) Studies on constituents of Iris genus plants. IV. The constituents of Iris florentina L. (2). Chemical and Pharmaceutical Bulletin, 21, 2323–2328.
12.
KachrooPK, RazdanTK, QurishiMA, KhurooMA, KoulS, DharKL. (1990) Two isoflavones from Iris kashmiriana. Phytochemistry, 29, 1014–1016.
13.
DharKL, KallaAK. (1973) New isoflavone from Iris germanica. Phytochemistry, 12, 734–735.
14.
SargentJM, TaylorCG. (1989) Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia. British Journal of Cancer, 60, 206–210.
