Nerolidol and its derivatives, namely cis-nerolidol, O-methyl-nerolidol, O-ethyl-nerolidol, (-)-α-bisabolol, trans, trans-farnesol and its main natural source cabreuva essential oil, were tested for their antimicrobial activity against airborne microbes and antifungal properties against plant pathogens. Among the tested compounds, α-bisabolol was the most effective antimicrobial agent and trans, trans-farnesol showed the best antifungal activity.
HolaJT, TaylorJH, DawsonDJ, HallKE. (2002) Biocide use in the food industry and the disinfectant resistance of persistent strains of Lysteria monocytogenes and Escherichia coli. Journal of Applied Microbiology, 92, 111–120.
2.
LevySB. (1998) The challenge of antibiotic resistance. Scientific American, 278, 46–53.
3.
Brehm-StecherBF, JohnsonEA. (2003) Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. Antimicrobial Agents and Chemotherapy, 47, 3357–3360.
4.
InoueY, ShiraishiA, HadaT, HiroseK, HamashimaH, ShimadaJ. (2004) The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. FEMS Microbiology Letters, 237, 325–331.
5.
HimejimaM, HobsonKR, OtsukaT, WoodDL, KuboI. (1992) Antimicrobial terpenes from oleoresin of ponderosa pine tree Pinus ponderosa: a defense mechanism against microbial invasion. Journal of Chemical Ecology, 18, 1809–1818.
6.
AmaralJA, EkinsA, RichardsSR, KnowlesR. (1998) Effect of selected monoterpenes on methane oxidation, denitrification, and aerobic metabolism by bacteria in pure culture. Applied Environmental Microbiology, 64, 520–525.
7.
NewmanAA. (1972) Chemistry of terpenes and terpenoids. Academic Press, London, United Kingdom.
8.
HarborneJB, Tomás-BarberánFA. (1991) Ecological chemistry and biochemistry of plant terpenoids. Oxford University Press, New York, N.Y.
9.
HarrewijnP, van OostenM, PironPG. (2001) Natural terpenoids as messengers: a multidisciplinary study of their production, biological functions, and practical applications. Kluwer Academic Publishers, Boston, Massachusetts.
10.
BauerK, GarbeD, SurburgH. (2006) Common fragrance and flavor materials: Preparation, properties and uses, 5th ed. Wiley-VCH, New York, N.Y.
11.
HornbyJM, JensenEC, LisecAD, TastoJJ, JahnkeB, ShoemakerR, DussaultP, NickersonKW. (2001) Quorum sensing in the dimorphic fungus candida albicans is mediated by farnesol. Applied Environmental Microbiology, 67, 2982–2992.
12.
SchubertV, DietrichA, UlrichT, MosandlA. (1992) The stereoisomers of nerolidol: separation, analysis and olfactoric properties. Zeitschrift für Naturforschung, C: Journal of Biosciences, 47, 304–307.
13.
LapczynskiA, BhatiaSP, LetiziaCS, ApiAM. (2008) Fragrance material review on cis-nerolidol. Food and Chemical Toxicology, 46, 245–246.
14.
LapczynskiA, BhatiaSP, LetiziaCS, ApiAM. (2008) Fragrance material review on nerolidol (isomer unspecified). Food and Chemical Toxicology. 46, 247–250.
15.
MoserK, KriwetK, NaikA, KaliaYN, GuyRH (2001) Passive skin penetration enhancement and its quantification in vitro. European Journal of Pharmaceutics and Biopharmaceutics, 52, 103–112.
16.
RyabchenkoB, TulupovaE, SchmidtE, WlcekK, BuchbauerG, JirovetzL. (2008) Investigation of anticancer and antiviral properties of selected aroma samples. Natural Products Communications, 3, 1085–1088.
17.
RyabchenkoB, TulupovaE, SchmidtE, JägerW, BuchbauerG, JirovetzL. (2011) Cytotoxic properties of selected sesquiterpene alcohols on human cervix carcinoma cell lines. Journal of Essential Oil Bearing Plants, 5, 316–319.
18.
KlopellFC, LemosM, SousaJPB, ComunelloE, MaistroEL, BastosJK, de AndradeSF. (2007) Nerolidol, an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae). Zeitschrift für Naturforschung, C: Journal of Biosciences, 62, 537–542.
19.
AldrichJR, WaiteGK, MooreC, PayneJA, LusbyWR, KochanskyJP. (1993) Male-specific volatiles from nearctic and Australasian true bugs (Heteroptera: Coreidae and Alydidae). Journal of Chemical Ecology, 19, 2767–2781.
20.
WannerJ, SchmidtE, BailS, JirovetzL, BuchbauerG, GochevV, GirovaT, AtanasovaT, StoyanovaA. (2010) Chemical composition and antibacterial activity of selected essential oils and some of their main compounds. Natural Product Communications, 5, 1359–1364.
21.
KamatouGPP, ViljoenAM. (2010) A review of the application and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. Journal of the American Oil Chemists’ Society, 87, 1–7.
22.
De LuccaAJ, PauliA, SchilcherH, SienT, BhatnagarD, WalshTJ. (2011) Fungicidal and bactericidal properties of bisabolol and dragostanol. Journal of Essential Oil Research, 23, 47–54.
23.
ThieleK, JakovlevV, IsaacO, SchulerW. (1969) Ethers and esters of (-)α-bisabolol and analogous mono- and sesquiterpenoids with antiinflammatory activity. Arzneimittel-Forschung, 19, 1878–1882.
24.
LeeI, JunH, JungE, HaJ, ParkD. (2010) Whitening effect of α-bisabolol in Asian woman subjects. International Journal of Cosmetic Science, 32, 299–303.
25.
MartinetzD, HartwigR. (1998) Taschenbuch der Riechstoffe: ein Lexikon von A-Z. Verlag Harri Deutsch, Frankfurt am Main, Germany.
26.
DevosSA, ConstandtL. (2002) Contact dermatitis from a dry stick deodorant. Contact Dermatitis, 47, 170–171.
27.
WannerJ, SchmidtE, BailS, JirovetzL, BuchbauerG, GochevV, GirovaT, AtanasovaT, StoyanovaA. (2010) Chemical composition, olfactory evaluation and antibacterial activity of selected essential oils and absolutes from Morocco. Natural Product Communications, 5, 1349–1354.
28.
DerengowskiLS, De-Souza-SilvaC, BrazSV, Mello-De-SousaTM, BáoSN, KyawCM, Silva-PereiraI. (2009) Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. Annals of Clinical Microbiology and Antimicrobials, 8.
29.
SimoesM, RochaS, CoimbraMA, VieraMJ (2008) Enhancement of Escherichia coli and Staphylococcus aureus antibiotic susceptibility using sesquiterpenoids. Medicinal Chemistry, 4, 616–623.
30.
SkaltsaHD, LazariDM, MavromatiAS, TilligadaEA, ConstantinidisTA (2000) Composition and antimicrobial activity of the essential oil of Scutellaria albida ssp. albida from Greece. Planta Medica, 66, 672–674.
31.
MooreRM, KaczmarekRG. (1991) Occupational hazards to healthcare workers: diverse, ill-defined and not fully appreciated. American Journal of Infection Control, 18, 316–327.
32.
SatoK, KristS, BuchbauerG. (2007) Antimicrobial effect of vapours of geraniol, (R)-(–)-linalool, terpineol, γ -terpinene and 1,8-cineole on airborne microbes using an airwasher. Flavour and Fragrance Journal, 22, 435–437.
33.
KristS, HalwachsL, SallabergerG, BuchbauerG. (2007) Effects of scents on airborne microbes, part I: thymol, eugenol, trans-cinnamaldehdye and linalool. Flavour and Fragrance Journal, 22, 44–48.
34.
KristS, SatoK, GlaslS, HoeferlM, SaukelJ. (2008) Antimicrobial effect of vapours of terpineol, (R)-(-)-linalool, carvacrol, (S)-(-)-perillaldehyde and 1,8-cineole on airborne microbes using a room diffuser. Flavour and Fragrance Journal, 23, 353–356.
35.
ChakrabartiA. (2005) Microbiology of systemic fungal infections. Journal of Postgraduate Medicine, 51, 16–20.
36.
GuptaAK, TomasE. (2003) New antifungal agents. Dermatologic Clinics, 21, 565–576.
37.
JensenPA, ToddWF, DavisGN, ScarpinoPV. (1992) Evaluation of eight bioaerosol samplers challenged with aerosols of free bacteria. American Industrial Hygiene Association Journal, 53, 660–667.
38.
WedgeD, KuhajekJ. (1998) Microbioassay for fungicide discovery. SAAS Bulletin, Biochemistry and Biotechnology, 11, 1–7.
