Trichostemonoate (1), a new tirucallane, together with four known compounds, 11α,20-dihydroxydammar-24-ene-3-one (2), sapelin E acetate (3), grandifolinolenenone (4) and α-mangostin (5), were isolated from the stem bark of Walsura trichostemon. The structural assignment of the new compound was based on spectroscopic methods. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines.
MaX., YuH. (2006) Global burden of cancer. Yale Journal of Biology and Medicine, 79, 85–94.
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(a) SichaemJ., AreeT., KhumkratokS., Jong-AramruangJ., Tip-PyangS. (2012) A new cytotoxic apotirucallane from the roots of Walsura trichostemon. Phytochemistry Letters, 5, 665–667; (b) Sichaem J, Siripong P, Tip-Pyang S, Phaopongthai J. (2014) A new cytotoxic tirucallane from the twigs of Walsura trichostemon. Natural Product Communications, 9, 367–368; (c) Sichaem J, Khumkratok S, Siripong P, Tip-Pyang S. (2014) New cytotoxic apotirucallanes from the leaves of Walsura trichostemon. Journal of Natural Medicines, 68, 436–441.
MitsuiK., SaitoH., YamamuraR., FukayaH., HitotsuyanagiY., TakeyaK. (2007) Apotirucallane and tirucallane triterpenoids from Cedrela sinensis. Chemical and Pharmaceutical Bulletin, 55, 1442–1447.
