Torrubiellone E (1), a new N-hydroxypyridone alkaloid, was isolated from the spider pathogenic fungus Torrubiella longissima BCC 2022, together with the known compounds, torrubiellones A (2) and B (3), and JBIR-130 (4). Compound 1 exhibited antimalarial activity against Plasmodium falciparum K1 with an IC50 value of 3.2 μg/mL, while it also showed weak cytotoxic activities.
JohnsonD, SungGH, Hywel-JonesNL, Juangsa-ardJJ, BischoffJF, KeplerRM, SpataforaJW. (2009) Systematics and evolution of the genus Torrubiella (Hypocreales, Ascomycota). Mycological Research, 113, 279–289.
2.
IsakaM, PalasarnS, SupothinaS, KomwijitS, Luangsa-ardJJ. (2011) Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627. Journal of Natural Products, 74, 782–789
3.
AsaiT, YamamotoT, OshimaY. (2011) Histone deacetylase inhibitor induced the production of three novel prenylated tryptophan analogs in the entomopathogenic fungus, Torrubiella luteorostrata. Tetrahedron Letters, 52, 7042–7045 and references cited therein.
4.
IsakaM, ChinthanomP, SupothinaS, TobwolP, Hywel-JonesNL. (2010) Pyridone and tetramic acid alkaloids from the spider pathogenic fungus Torrubiella sp. BCC 2165. Journal of Natural Products, 73, 2057–2060
5.
IsakaM, PalasarnS, TobworP, BoonruangprapaT, TasanathaiK. (2012) Bioactive anthraquinone dimers from the leafhopper pathogenic fungus Torrubiella sp. BCC 28517. Journal of Antibiotics, 65, 571–574.
6.
HosoyaT, TakagiM, Shin-yaK. (2013) New pyridone alkaloids JBIR-130, JBIR-131 and JBIR-132 from Isaria sp. NBRC 104353. Journal of Antibiotics, 66, 235–238
7.
JessenHJ, SchumacherA, SchmidF, PfaltzA, GademannK. (2011) Catalytic enantioselective total synthesis of (+)-torrubiellone C. Organic Letters, 13, 4368–4370
8.
DingF, WilliamR, LeowML, ChaiH, FongJZM, LiuXW. (2014) Directed orthometalation and the asymmetric total synthesis of N-deoxymilitarinone A and torrubiellone B. Organic Letters, 16, 26–29
9.
MaC, LiY, NiuS, ZhangH, LiuX, CheY. (2011) N- Hydroxypyridones, phenylhydrazones, and a quinazolinone from Isaria farinosa. Journal of Natural Products, 74, 32–37.
10.
DesjardinsRE, CanfieldCJ, HaynesJD, ChulayJD. (1979) Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrobial Agents and Chemotherapy, 16, 710–718
11.
O'BrienJ, WilsonI, OrtonT, PognanF. (2000) Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. European Journal of Biochemistry, 267, 5421–5426
12.
ChangsenC, FranzblauSG, PalittapongarnpimP. (2003) Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetaminase promoter. Antimicrobial Agents and Chemotherapy, 47, 3682–3687.
