One new diterpenoid, 11α,12βH-dolabella-4,8(17)-dien-3α,7β,18-triol (1) and one new sesquilignan, 9-methoxy-7′,8′-cis–7″,8″-cis-buddlenol B (2), together with three known compounds, (+)-diasyringaresinol (3), N-methyl-5- hydroxy-Δ3-pyrrolin-2-one (4) and marmin (5), have been isolated from Aglaia odorata var. microphyllina. Their structures were determined using 1D and 2D NMR spectroscopy. Compound 1 exhibited cytotoxic activity against the K562 cell line with an IC50 value of 12.5 μg/mL.
PannellC.M. (2007) Aglaia. In Tree Flora of Sabah and Sarawak. Soepadmo E, Saw LG, Chung RCK, Kiew R (Eds). Ampang Press Sdn Bhd, Kuala Lumpur, p 24; (b) Cai XH, Wang YY, Zhao PJ, Li Y, Luo XD. (2010) Dolabellane diterpenoids from Aglaia odorata. Phytochemistry, 71, 1020–1024; (c) Houghton P. (1985) Lignans and neolignans from Buddleja davidii. Phytochemistry, 24, 819–826.
2.
ChangF.R., ChaoY.C., TengC.M., WuY.C. (1998) Chemical constituents from Cassytha filiformis I. Journal of Natural Products, 61, 863–866.
3.
LightnerD.A., BisacchiG.S., NorrisR.D. (1976) On the mechanism of the sensitized photooxygenation of pyrroles. Journal of the American Chemical Society, 98, 802–807; (b) Yamada Y, Nakatani N, Fuwa H. (1987) Epoxyaurapten and marmin from juice oil in Hassaku (Citrus hassaku) and the spasmolytic activity of 7-geranyloxycoumarin-related compounds. Agricultural & Biological Chemistry, 51, 1105–1110.
4.
NugrohoA.E., SahidN.A., RiyantoS., MaeyamaK., IkawatiZ. (2011) Effects of marmin isolated from Aegle marmelos Correa on L-histidine decarboxylase enzyme in RBL-2H3 cells. The Thai Journal of Pharmaceutical Sciences, 35, 1–7; (b) Nugroho AE, Anas Y, Arsito PN, Wibowo JT, Riyanto S, Sukari MA. (2011) Effects of marmin, a compound isolated from Aegle marmelos Correa, on contraction of the guinea pig-isolated trachea. Pakistan Journal of Pharmaceutical Sciences, 24, 427–433; (c) Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. Journal of Immunological Methods, 65, 55–63.
