A New Dolabellane Diterpenoid and a Sesquilignan from Aglaia odorata var. microphyllina

Abstract

One new diterpenoid, 11α,12βH-dolabella-4,8(17)-dien-3α,7β,18-triol (1) and one new sesquilignan, 9-methoxy-7′,8′-cis–7″,8″-cis-buddlenol B (2), together with three known compounds, (+)-diasyringaresinol (3), N-methyl-5- hydroxy-Δ³-pyrrolin-2-one (4) and marmin (5), have been isolated from Aglaia odorata var. microphyllina. Their structures were determined using 1D and 2D NMR spectroscopy. Compound 1 exhibited cytotoxic activity against the K562 cell line with an IC₅₀ value of 12.5 μg/mL.

Keywords

Dolabellane diterpenoid Sesquilignan

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