A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides (1–3) and other phenolic compounds (4–8). To evaluate their anti-allergic and anti-inflammatory activities, the isolates (1–8) were tested for their inhibitory effects on histamine release and on the gene expressions of tumor necrosis factor (TNF)-α and interleukin (IL)–6 in human mast cells. Of these, phenolic glycosides 7 and 8 suppressed histamine release and inhibited the pro-inflammatory cytokines TNF-α and IL-6. These results suggest that isolates from P. persica are among the anti-allergic inflammatory principles in this medicinal plant.
BarnesP.J. (2011) Pathophysiology of allergic inflammation. Immunological Reviews, 242, 31–50; (b) Kim SH, Jun CD, Suk K, Choi BJ, Lim H, Park S, Lee SH, Shin HY, Kim DK, Shin TY. (2006) Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicological Sciences, 91, 123–131.
2.
FrankS.S.J. (1998) Amygdalin in Prunus leaves. Phytochemistry, 47, 1537–1538; (b) Kosuge T, Ishida H, Ishii M. (1985) Studies on active substances in the herbs used for Oketsu (“Stagnant Blood”) in Chinese medicine. II. On the anticoagulative principle in Persicae semen. Chemical & Pharmaceutical Bulletin, 33, 1496–1498; (c) Fukuda T, Ito H, Mukainaka T, Tokuda H, Nishino H, Yoshida T. (2003) Anti-tumor promoting effect of glycosides from Prunus persica seeds. Biological & Pharmaceutical Bulletin, 26, 271–273; (d) Wu H, Shi J, Xue S, Kakuda Y, Wang D, Jiang Y, Ye X, Li Y, Subramanian J. (2011) Essential oil extracted from peach (Prunus persica) kernel and its physicochemical and antioxidant properties. LWT-Food Science and Technology, 44, 2032–2039; (e) Hwang HJ, Kim P, Kim CJ, Lee HJ, Shim I, Yin CS, Yang Y, Hahm DH. (2008) Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. Biological & Pharmaceutical Bulletin, 31, 1559–1564; (f) Yun-Choi HS, Kim, SO, Kim JH, Lee JR, Cho HI. (1985) Modified smear method for screening potential inhibitors of platelet aggregation from plant sources. Journal of Natural Products, 48, 363–370.
3.
ShinT.Y., ParkS.B., YooJ.S., KimI.K., LeeH.S., KwonT.K., KimM.K., KimJ.C., KimS.H. (2010) Anti-allergic inflammatory activity of the fruit of Prunus persica: role of calcium and NF-κB. Food and Chemical Toxicology, 48, 2797–2802.
4.
ChinY.W., ChaiH.B., KellerW.J., KinghornA.D. (2008) Lignans and other constituents of the fruits of Euterpe oleracea (Acai) with antioxidant and cytoprotective activities. Journal of Agricultural and Food Chemistry, 56, 7759–7764; (b) Anthony AR. (1990) 1H and 13C NMR analysis of D-amygdalin: oligosaccharide assignment and sequencing. Magnetic Resonance in Chemistry, 28, 765–773; (c) Wang M, Li J, Rangarajan M, Shao Y, LaVoie EJ, Huang TC, Ho CT. (1998) Antioxidative phenolic compounds from sage (Salvia officinalis). Journal of Agricultural and Food Chemistry, 46, 4869–4873; (d) Abe F, Yamauchi T. (1986) Lignans from Trachelospermum asiaticum (Tracheolospermum) II. Chemical and Pharmaceutical Bulletin, 34, 4340–4345; (e) Ida Y, Satoh Y, Ohtsuka M, Nagasao M, Shoji J. (1993) Phenolic constituents of Phellodendron amurense Bark. Phytochemistry, 35, 209–215; (f) Perold GW, Beylis P, Howard AS. (1973) Metabolites of proteaceae. Part VII. Lacticolorin, a phenolic glucoside ester, and other metabolites of Protea lacticolor Salisb. Journal of the Chemical Society, Perkin Transaction I, 6, 638–643.
