An EtOAc extract of the cultured soft coral Sinularia gibberosa yielded a new cembrane-based diterpenoid, cugibberosene A (1), together with the previously reported three cembranoids (2–4). The structure determination was based on extensive NMR studies. The cytotoxic and antibacterial activities of these isolated metabolites 1–4 were evaluated in vitro.
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