To continue our search for natural product-based compounds for the control of Brontispa longissima larvae, eight spin-labeled podophyllotoxin derivatives (4a-h) and the intermediates 2 and 3 were tested for their insect antifeedant activity against third-instar larvae of B. longissima. Among all the tested compounds, 4a, 4c, 2 and 3 showed pronounced antifeedant activities with AFC50 values of 0.16, 0.31, 0.15 and 0.28 mg/mL, respectively. The different antifeedant activity ranges of these compounds indicated that variation of the structures of L-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it.
LvBQ, TangC, PengZQ, La SalleJ, WanFH. (2008) Biological assessment in quarantine of Asecodes hispinarum Boucek (Hymenoptera: Eulophidae) as an imported biological control agent of Brontispa longissima (Gestro) (Coleoptera: Hispidae) in Hainan, China. Biological Control, 45, 29–35.
2.
SuZ, DengLH, YiXP, XiaoSS, ZhangCF. (2009) The biocontrol of Brontispa longissima. Genomics and Applied Biology, 28, 405–407.
3.
LuoYP, CaiDC, ZhuZH, HuangGD. (2005) Efficacy of several insecticides against Brontispa longissima. Chinese Journal of Pesticides, 44, 142–143.
4.
XieSH, ChenMC, RuiK, XiaoTB, KongXY, WuFZ. (2007) The measurement of toxicity of 36 pesticides against Brontispa longissima. Natural Science Journal of Hainan University, 25, 57–61.
5.
ScottIM, JensenH, ScottJG, IsmanMB, ArnasonJT, PhilogeneBJR. (2003) Botanical insecticides for controlling agricultural pests: piperamides and the Colorado potato beetle Leptinotarsa decemlineata Cay (Coleoptera: Chrysomelidae). Archives of Insect Biochemistry and Physiology, 54, 212–225.
6.
GarciaES, AzambujaP., (2004) Lignoids in insects: chemical probes for the study of ecdysis, excretion and Trypanosoma cruzi—triatomine interactions. Toxicon, 44, 431–440.
7.
ShaalanEAS, CanyonD, YounesMWF, Abde-WahabH, MansourAH. (2005) A review of botanical phytochemicals with mosquitocidal potential. Environment International, 31, 1149–1166.
8.
DiXD, LiuYQ, LiuYQ, YuXY, XiaoH, TianX, GaoR., (2007) Synthesis and insecticidal activities of pyridine ring derivatives of podophyllotoxin. Pesticide Biochemistry and Physiology, 89, 81–87.
9.
GaoR, GaoCF, TianX, YuXY, DiXD, XiaoH, ZhangX., (2004) Insecticidal activity of deoxypodophyllotoxin, isolated from Juniperus sabina L, and related lignans against larvae of Pieris rapae L. Pest Management Science, 60, 1131–1136.
10.
LiuYQ, LiuYQ, XiaoH, GaoR, TianX., (2008) Synthesis and insecticidal activities of novel derivatives of podophyllotoxin: Part XII. Pesticide Biochemistry and Physiology, 91, 116–121.
11.
XuH, WangJJ, SunHJ, LvM, TianX, YaoXJ, ZhangX., (2009) Semisynthesis and quantitative structure-activity relationship (QSAR) study of novel aromatic esters of 4′-demethyl-4-deoxypodophyllotoxin as insecticidal agents. Journal of Agricultural and Food Chemistry, 57, 7919–7923.
12.
ZhangJ, LiuYQ, YangL, FengG., (2009) Podophyllotoxin derivatives show activity against Brontispa longissima larvae. Natural Product Communications, 4, 1247–1250.
13.
LiuYQ, TianX., (2005) Synthesis of novel spin-labeled derivatives of podophyllotoxin as potential antineoplastic agents. Synthetic Communications, 35, 2749–2758.
