The cancer chemopreventive potential of sarcophine-diol in a chemical carcinogen initiation–promotion experimental tumor model in mice was evaluated. Sarcophine-diol, when given orally, afforded significant protection in the mouse skin cancer model initiated by the topical administration of (±)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). These findings, along with our initial reports, suggest that sarcophine-diol is an effective cancer chemopreventive agent, even when administered orally and at a very low dose and thus indicating possible potential human applications in the control of malignancy.
KatsuyamaI, FahmyH, ZjawionyJK, KhalifaS, KiladaRW, KonoshimaT, TakasakiM, TokudaH., (2002) Semisynthesis of new sarcophine derivatives with chemopreventive activity. Journal of Natural Products, 65, 1809–1814;
7.
FahmyH, KhalifaS, KonoshimaT, ZjawionyJK. (2004) An improved synthesis of 7,8-epoxy-1,3,11-cembratriene-15R (α), 16-diol, a cembranoid of marine origin with a potent cancer chemopreventive activity. Marine Drugs, 2, 1–7;
8.
FahmyH, ZjawionyJK, KonoshimaT, TokudaH, KhanS, KhalifaS., (2006) Potent skin cancer chemopreventiing activity of some novel semi-synthesis cembranoids from marine sources. Marine Drugs, 4, 1–9;
9.
ZhangX, KundoorV, KhalifaS, ZemanD, FahmyH, DwivediC., (2007) Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice. Cancer Letters, 253, 53–59;
10.
KundorV, ZhangX, KhalifaS, FahmyH, DwivediC., (2006) A possible mechanism of action of the chemopreventive effects of sarcotriol on skin tumor development in CD-1 mice. Marine Drugs, 4, 274–285;
11.
ZhangX, BommareddyA, ChenW, HildrethMB, KaushikRS, ZemanD, KhalifaS, FahmyH, DwivediC., (2009) Chemopreventive effects of sarcophine-diol on ultraviolet B-induced skin tumor development in SKH-1 hairless mice. Marine Drugs, 7, 153–165;
12.
KundooV, ZhangX, BommareddyA, KhalifaS, FahmyH, DwevediC., (2007) Chemopreventive effects of sacrotriol in ultraviolet B-induced skin tumor development in SKH-1 hairless mice. Marine Drugs, 5, 197–207;
13.
ZhangX, BommareddyA, ChenW, KhalifaS, KaushikRS, FahmyH, DwivediC., (2009) Sarcophine-diol, a chemopreventive agent of skin cancer, inhibits cell growth and induces apoptosis through extrinsic pathway in human epidermoid carcinoma A431 cells. Translational Oncology, 2, 21–30;
